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Differential Diagnosis for Soft Tissue Lump on Foot

Single Most Likely Diagnosis

  • Lipoma: A benign tumor composed of fat tissue, which is the most common soft tissue tumor and can occur on the foot, presenting as a soft, movable lump.

Other Likely Diagnoses

  • Cyst: Such as a ganglion cyst or a synovial cyst, which are fluid-filled lumps that can occur on the foot due to wear and tear or trauma.
  • Bursitis: Inflammation of a bursa, a fluid-filled sac that cushions joints and reduces friction, which can cause a soft tissue lump on the foot.
  • Abscess: A collection of pus that has built up within the tissue of the foot, often caused by a bacterial infection, which can present as a painful lump.
  • Wart: A viral infection caused by the human papillomavirus (HPV), which can cause a lump on the foot, especially on the sole (plantar wart).

Do Not Miss Diagnoses

  • Malignant Tumor: Such as a soft tissue sarcoma (e.g., liposarcoma, leiomyosarcoma), which, although rare, can present as a lump on the foot and requires early diagnosis for effective treatment.
  • Infectious Process: Like osteomyelitis (bone infection) or septic arthritis (joint infection), which can cause a lump on the foot and are medical emergencies.
  • Deep Vein Thrombosis (DVT): A blood clot in a deep vein, which can cause swelling and a lump in the foot or leg, and is a medical emergency due to the risk of pulmonary embolism.

Rare Diagnoses

  • Neurofibroma: A benign tumor of the nerve tissue, which can occur on the foot and is associated with neurofibromatosis type 1 (NF1).
  • Glomus Tumor: A rare, benign tumor of the glomus body, a specialized vascular structure, which can occur under the nail or on the foot and is often painful.
  • Sweat Gland Tumors: Such as hidradenoma or eccrine spiradenoma, which are rare, benign tumors of the sweat glands that can occur on the foot.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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