Differential Diagnosis for Soft Tissue Lump on Foot
Single Most Likely Diagnosis
- Lipoma: A benign tumor composed of fat tissue, which is the most common soft tissue tumor and can occur on the foot, presenting as a soft, movable lump.
Other Likely Diagnoses
- Cyst: Such as a ganglion cyst or a synovial cyst, which are fluid-filled lumps that can occur on the foot due to wear and tear or trauma.
- Bursitis: Inflammation of a bursa, a fluid-filled sac that cushions joints and reduces friction, which can cause a soft tissue lump on the foot.
- Abscess: A collection of pus that has built up within the tissue of the foot, often caused by a bacterial infection, which can present as a painful lump.
- Wart: A viral infection caused by the human papillomavirus (HPV), which can cause a lump on the foot, especially on the sole (plantar wart).
Do Not Miss Diagnoses
- Malignant Tumor: Such as a soft tissue sarcoma (e.g., liposarcoma, leiomyosarcoma), which, although rare, can present as a lump on the foot and requires early diagnosis for effective treatment.
- Infectious Process: Like osteomyelitis (bone infection) or septic arthritis (joint infection), which can cause a lump on the foot and are medical emergencies.
- Deep Vein Thrombosis (DVT): A blood clot in a deep vein, which can cause swelling and a lump in the foot or leg, and is a medical emergency due to the risk of pulmonary embolism.
Rare Diagnoses
- Neurofibroma: A benign tumor of the nerve tissue, which can occur on the foot and is associated with neurofibromatosis type 1 (NF1).
- Glomus Tumor: A rare, benign tumor of the glomus body, a specialized vascular structure, which can occur under the nail or on the foot and is often painful.
- Sweat Gland Tumors: Such as hidradenoma or eccrine spiradenoma, which are rare, benign tumors of the sweat glands that can occur on the foot.