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Differential Diagnosis for Hematuria and Proteinuria in a 20yo Male

Single Most Likely Diagnosis

  • IgA Nephropathy: This is the most common cause of hematuria and proteinuria in young adults, often presenting with recurrent episodes of gross hematuria, especially following upper respiratory tract infections.

Other Likely Diagnoses

  • Alport Syndrome: A genetic disorder characterized by hematuria, proteinuria, and progressive kidney disease, often associated with hearing loss and eye abnormalities.
  • Thin Basement Membrane Nephropathy: A benign condition that can cause hematuria and mild proteinuria, often with a family history of similar symptoms.
  • Nephrotic Syndrome: A collection of symptoms including heavy proteinuria, hypoalbuminemia, and edema, which can be caused by various glomerular diseases, such as minimal change disease or focal segmental glomerulosclerosis.

Do Not Miss Diagnoses

  • Goodpasture Syndrome: A rare autoimmune disease that can cause rapidly progressive glomerulonephritis, hematuria, and proteinuria, often associated with pulmonary hemorrhage.
  • Wegener's Granulomatosis (Granulomatosis with Polyangiitis): A systemic vasculitis that can cause renal involvement, hematuria, and proteinuria, often with respiratory and other systemic symptoms.
  • Lupus Nephritis: A complication of systemic lupus erythematosus that can cause hematuria, proteinuria, and kidney failure, often with other systemic symptoms such as joint pain and skin rashes.

Rare Diagnoses

  • Membranoproliferative Glomerulonephritis: A rare glomerular disease that can cause hematuria, proteinuria, and kidney failure, often associated with complement system abnormalities.
  • Fabry Disease: A genetic disorder that can cause hematuria, proteinuria, and kidney failure, often associated with other systemic symptoms such as neuropathic pain and skin lesions.
  • Sickle Cell Nephropathy: A complication of sickle cell disease that can cause hematuria, proteinuria, and kidney failure, often with other systemic symptoms such as anemia and pain crises.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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