Does Tramadol (tramadol hydrochloride) suppress cough?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Article Review Status
Submitted
Under Review
Approved

Last updated: February 10, 2025 • View editorial policy

From the Research

Tramadol's Effect on Cough Suppression

  • Tramadol has been studied for its potential to suppress cough in various clinical trials and studies 1, 2, 3, 4.
  • A study published in 2009 found that tramadol was effective in controlling cough in a patient with chronic cough caused by interstitial pneumopathy 1.
  • Another study published in 2021 discussed the possible beneficial effects of using tramadol against SARS-CoV-2 infection, including its anti-inflammatory and immune-enhancing effects, and its potential to suppress COVID-19-related cough 2.
  • Research published in 1998 evaluated the antitussive activity of tramadol and other drugs, finding that tramadol decreased cough parameters in unanesthetized cats 3.
  • A 1992 study compared the effects of codeine and tramadol on laryngeal reactivity, finding that tramadol increased the concentration of ammonia required to induce a glottic stop, suggesting a depressive effect on laryngeal reflex activity 4.

Mechanisms of Action

  • Tramadol's antitussive effects may be mediated by its action on opioid receptors, as well as its effects on noradrenergic and serotonergic mechanisms 2, 4.
  • The drug's anti-inflammatory and immune-enhancing effects may also contribute to its potential to suppress cough 2.
  • Gabaergic, serotoninergic systems, and activity of NMDA receptors may play a role in the mechanism of action of antitussive drugs, including tramadol 3.

Clinical Implications

  • Tramadol may be a useful treatment option for patients with chronic cough or COVID-19-related cough, although further studies are needed to confirm its effectiveness 1, 2.
  • The drug's potential benefits and risks should be carefully considered by healthcare professionals when prescribing tramadol for cough suppression 5.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.