From the Research
Tramadol's Effect on Cough Suppression
- Tramadol has been studied for its potential to suppress cough in various clinical trials and studies 1, 2, 3, 4.
- A study published in 2009 found that tramadol was effective in controlling cough in a patient with chronic cough caused by interstitial pneumopathy 1.
- Another study published in 2021 discussed the possible beneficial effects of using tramadol against SARS-CoV-2 infection, including its anti-inflammatory and immune-enhancing effects, and its potential to suppress COVID-19-related cough 2.
- Research published in 1998 evaluated the antitussive activity of tramadol and other drugs, finding that tramadol decreased cough parameters in unanesthetized cats 3.
- A 1992 study compared the effects of codeine and tramadol on laryngeal reactivity, finding that tramadol increased the concentration of ammonia required to induce a glottic stop, suggesting a depressive effect on laryngeal reflex activity 4.
Mechanisms of Action
- Tramadol's antitussive effects may be mediated by its action on opioid receptors, as well as its effects on noradrenergic and serotonergic mechanisms 2, 4.
- The drug's anti-inflammatory and immune-enhancing effects may also contribute to its potential to suppress cough 2.
- Gabaergic, serotoninergic systems, and activity of NMDA receptors may play a role in the mechanism of action of antitussive drugs, including tramadol 3.
Clinical Implications
- Tramadol may be a useful treatment option for patients with chronic cough or COVID-19-related cough, although further studies are needed to confirm its effectiveness 1, 2.
- The drug's potential benefits and risks should be carefully considered by healthcare professionals when prescribing tramadol for cough suppression 5.