From the Guidelines
THC gummies are more effective than CBD gummies for managing cancer treatment-related toxicities, palliation of cancer symptoms, or improvement of quality of life (QOL) with cancer, as evidenced by the limited high-quality clinical evidence available 1. When considering the use of THC or CBD gummies, it's essential to weigh the potential benefits and drawbacks of each option.
- THC gummies have shown varying effects, including pain relief, improved appetite, and improved sleep, but also dysphoria and slight worsening of QOL 1.
- In contrast, there is only one study evaluating CBD, which focused on symptom burden, and the current evidence is limited 1.
- Synthetic cannabinoids, such as dronabinol and nabilone, may be used as salvage antiemetics in cases of refractory chemotherapy-induced nausea and vomiting (CINV) 1.
- The dosage of oral dronabinol can be started at 2.5 mg three times a day and up-titrated to 10 mg three to four times daily, while oral nabilone can be initiated at 1 mg twice daily and up-titrated as needed 1. It's crucial to consult with a healthcare provider before using either THC or CBD gummies, especially if you're taking other medications, as both compounds can interact with certain drugs.
- Starting with low doses and gradually increasing as needed can help find the optimal therapeutic dose while minimizing unwanted effects.
- However, the current evidence suggests that THC gummies may be a more effective option for managing cancer-related symptoms, despite the potential side effects 1.
From the Research
Comparison of THC and CBD Gummies
- There is no direct comparison of the effectiveness of Tetrahydrocannabinol (THC) gummies and Cannabidiol (CBD) gummies in the provided studies.
- However, the studies suggest that CBD has various therapeutic benefits, including anti-inflammatory, antiepileptic, anxiolytic, and anticancer properties 2, 3, 4, 5.
- CBD is also reported to have antipyretic effects, reducing fever and inflammation in lipopolysaccharide (LPS)-induced fever 4.
- THC, on the other hand, is known for its psychoactive effects and is responsible for the euphoric and hallucinogenic effects associated with cannabis use 6.
- It is worth noting that CBD products, including gummies, may contain inconsistent strengths of CBD or even THC, which can affect their effectiveness and safety 2.
Therapeutic Applications of CBD
- CBD has been studied for its potential therapeutic effects in various medical and psychiatric conditions, including depression, anxiety, post-traumatic stress disorder, Alzheimer's disease, and pain 2, 5.
- CBD has also been shown to have anticancer properties, particularly when combined with photodynamic therapy 3.
- The studies suggest that CBD is a promising therapeutic agent with a range of potential applications, but more research is needed to fully understand its effects and optimal uses 2, 3, 4, 5.
Safety and Efficacy of CBD Gummies
- The safety and efficacy of CBD gummies are not directly addressed in the provided studies.
- However, the studies suggest that CBD is generally well-tolerated and has a low risk of abuse 4.
- It is essential to note that the quality and consistency of CBD products, including gummies, can vary widely, and more research is needed to ensure their safety and efficacy 2.