Recommended Dosage of Fluticasone Nasal Spray in Adults
For adults, the recommended dosage of Fluticasone Propionate Nasal Spray is 2 sprays (50 mcg each) in each nostril once daily, for a total daily dose of 200 mcg. 1
Standard Dosing Regimens
- The FDA-approved standard dosage for adults is 2 sprays (50 mcg each) in each nostril once daily (total: 200 mcg) 1
- An alternative regimen is the same total dosage (200 mcg) divided into 100 mcg given twice daily (e.g., morning and evening) 1
- After the first few days of treatment, some patients may be able to reduce their dosage to 1 spray in each nostril (100 mcg total) once daily for maintenance therapy 1, 2
Efficacy of Once-Daily vs Twice-Daily Dosing
- Clinical studies have demonstrated that once-daily dosing (200 mcg) is as effective as twice-daily dosing for treating allergic rhinitis 3, 4
- The convenience of once-daily dosing may improve patient compliance with treatment 5
- Morning administration of the once-daily dose has shown effectiveness in controlling symptoms throughout the 24-hour period 3, 5
Maintenance Therapy Considerations
- For seasonal allergic rhinitis, some patients (12 years and older) may benefit from as-needed use of 200 mcg once daily for symptom control 1
- Greater symptom control is generally achieved with scheduled regular use rather than as-needed use 1
- Clinical studies show that fluticasone propionate administered once daily in the morning is safe and effective for both seasonal and perennial allergic rhinitis 3, 4
Common Side Effects
- Headache, pharyngitis, epistaxis (nose bleeds), nasal burning or irritation 2
- Nausea, vomiting, asthma symptoms, and cough may also occur 2
- The incidence of adverse events is similar between once-daily and twice-daily dosing regimens 3, 5
Important Administration Guidelines
- Patients should use fluticasone nasal spray at regular intervals for optimal effect 1
- The spray should be administered according to the illustrated patient instructions that accompany each package 1
- Blood in nasal mucus may be more common with twice-daily dosing regimens compared to once-daily dosing 3
Special Considerations
- Fluticasone propionate is contraindicated in patients with a history of hypersensitivity to fluticasone or its components 2
- There is no evidence of systemic effects or hypothalamic-pituitary-adrenal axis suppression with recommended doses 3, 5
Remember that while the standard adult dose is 200 mcg total daily (as 2 sprays in each nostril once daily), the dosage may be reduced to 100 mcg daily for maintenance therapy once adequate symptom control is achieved.