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Last updated: October 8, 2025View editorial policy

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Differential Diagnosis for Coughing up Blood

Single most likely diagnosis

  • Chronic Bronchitis: This condition is a common cause of coughing up blood (hemoptysis) due to chronic inflammation and irritation of the bronchial tubes, often associated with smoking or long-term exposure to pollutants.

Other Likely diagnoses

  • Pneumonia: Bacterial, viral, or fungal infections can cause inflammation of the lungs, leading to hemoptysis.
  • Bronchiectasis: A condition characterized by damaged, dilated airways, which can result in chronic cough and hemoptysis.
  • Lung Cancer: Tumors in the lungs can cause bleeding, leading to coughing up blood.
  • Tuberculosis (TB): A bacterial infection that can cause hemoptysis, especially in advanced stages.

Do Not Miss (ddxs that may not be likely, but would be deadly if missed)

  • Pulmonary Embolism (PE): A blood clot in the lungs can cause sudden, severe hemoptysis, and is a medical emergency.
  • Aortic Aneurysm or Dissection: Although rare, these conditions can cause hemoptysis due to erosion of the aorta into the airways.
  • Goodpasture Syndrome: A rare autoimmune disease that can cause bleeding in the lungs and kidneys.

Rare diagnoses

  • Cystic Fibrosis: A genetic disorder that can cause chronic respiratory infections and hemoptysis.
  • Wegener's Granulomatosis (Granulomatosis with Polyangiitis): A rare autoimmune disease that can cause inflammation and bleeding in the lungs.
  • Mitral Stenosis: A heart condition that can cause increased pressure in the lungs, leading to hemoptysis.
  • Arteriovenous Malformation (AVM): A rare congenital condition that can cause abnormal connections between blood vessels, leading to hemoptysis.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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