Differential Diagnosis for White Patch on Labia

• Single most likely diagnosis
  • Lichen sclerosus: This condition is characterized by thin, white, patchy skin that is often seen on the genital and anal areas. It can cause itching, pain, and tearing of the skin.
• Other Likely diagnoses
  • Lichen planus: An inflammatory condition that can affect the skin and mucous membranes, including the genital area, causing white patches and itching.
  • Vitiligo: A condition where the skin loses its pigment cells, resulting in white patches. Although less common in the genital area, it can occur.
  • Candidiasis (yeast infection): Can cause white patches on the labia, especially if the infection is severe.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Squamous cell carcinoma: Although rare, this type of skin cancer can present as a white patch on the labia. Early detection is crucial for effective treatment.
  • Extramammary Paget's disease: A rare skin cancer that can appear as a white patch in the genital area, often accompanied by itching and bleeding.
• Rare diagnoses
  • Leucoplakia: A condition characterized by white patches on mucous membranes, including the genital area, which can be a precursor to cancer.
  • Scleroderma: A chronic autoimmune disease that can cause skin thickening and white patches, although it is rare in the genital area.
  • Pemphigus: A group of autoimmune diseases that can cause blistering of the skin and mucous membranes, including the genital area, and may present with white patches.