Carotenemia: This condition is caused by an excess of carotenoids in the blood, often due to a diet rich in carrots, sweet potatoes, or other carotenoid-containing foods. It leads to a harmless but noticeable orange discoloration of the skin, particularly on the palms, soles, and face.

Lycopenemia: Similar to carotenemia, lycopenemia is caused by an excessive intake of lycopene-rich foods like tomatoes. It can cause a yellow or orange hue on the skin.
Jaundice: While jaundice typically causes a yellow discoloration, in some cases, especially when mixed with other pigments, it might appear more orange. It's a sign of liver dysfunction or bile duct obstruction.
Hyperbilirubinemia: Elevated levels of bilirubin can cause skin discoloration, which might appear orange, especially in individuals with mixed hyperbilirubinemia.

Hypothyroidism: Though less common, hypothyroidism can cause carotenemia due to decreased conversion of carotene to vitamin A, leading to orange skin discoloration. Missing this diagnosis could lead to untreated hypothyroidism, which has significant health implications.
Liver Disease: Certain liver diseases can lead to an accumulation of carotenoids or other substances causing orange skin. Missing a liver disease diagnosis could have serious health consequences if left untreated.
Lymphoma: Some types of lymphoma can cause orange skin due to the accumulation of carotenoids or other substances. Missing this diagnosis could delay necessary cancer treatment.

Apocarotenoidism: A rare condition where the body cannot convert carotene into vitamin A, leading to carotenemia.
Erythema palmare hereditarium (Red Palm): Though not typically orange, this rare genetic condition causes red discoloration of the palms and soles and could potentially be confused with orange skin discoloration in some cases.
Pellagra: Caused by niacin deficiency, pellagra can lead to skin changes, including hyperpigmentation, which might appear orange in some cases, especially when exposed to sunlight.