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Last updated: October 8, 2025View editorial policy

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Differential Diagnosis for Headaches and Cheek Twitching

  • Single Most Likely Diagnosis
    • Migraine with facial twitching: This is a common condition that can cause headaches and facial twitching, including cheek twitching. The twitching can be a symptom of the migraine aura or a side effect of the migraine itself.
  • Other Likely Diagnoses
    • Hemifacial spasm: A rare neurological disorder characterized by irregular, involuntary muscle contractions on one side of the face, which can cause cheek twitching and may be accompanied by headaches.
    • Trigeminal neuralgia: A chronic pain condition that affects the trigeminal nerve, which can cause severe headaches and facial pain, including cheek twitching.
    • Temporomandibular joint (TMJ) disorder: A condition that affects the joint that connects the jawbone to the skull, which can cause headaches, facial pain, and cheek twitching.
  • Do Not Miss Diagnoses
    • Multiple sclerosis: A chronic and often disabling autoimmune disease that can cause a wide range of symptoms, including headaches, facial twitching, and vision problems. Although it is not a common cause of cheek twitching, it is a potentially serious condition that should not be missed.
    • Stroke or transient ischemic attack (TIA): A sudden loss of brain function caused by a blockage or rupture of the blood vessels supplying the brain, which can cause headaches, facial weakness, and twitching.
    • Brain tumor: A mass of abnormal cells in the brain that can cause a variety of symptoms, including headaches, facial twitching, and vision problems.
  • Rare Diagnoses
    • Dystonia: A neurological disorder characterized by involuntary muscle contractions, which can cause facial twitching and other abnormal movements.
    • Facial myokymia: A rare condition characterized by involuntary, wave-like contractions of the facial muscles, which can cause cheek twitching.
    • Botulism: A rare but serious illness caused by a toxin produced by the bacteria Clostridium botulinum, which can cause muscle weakness, facial twitching, and other symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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