From the FDA Drug Label
Adverse reactions reported in at least 2% of NEXLETOL-treated patients and more frequently than in placebo-treated patients are shown in Table 1. Table 1 Adverse Reactions (≥ 2% and greater than placebo) in NEXLETOL-Treated Patients with Primary Hyperlipidemia and CVD or HeFH (Trials 2 and 3) Adverse ReactionPlacebo* (N = 999) %NEXLETOL* (N = 2,009) % ... Pain in extremity1.73.0
The cause of forearm pain in a patient taking Nexletol (bempedoic acid) may be pain in extremity, which is a reported adverse reaction in patients treated with NEXLETOL 1.
From the Research
If you're experiencing forearm pain while taking Nexletol (bempedoic acid), you should contact your healthcare provider to report this side effect, as muscle pain, including in the forearms, is a known potential side effect of Nexletol, though it occurs less frequently than with statins. According to the most recent and highest quality study available 2, bempedoic acid is generally safe and well-tolerated, with myalgia being the most common muscle-related adverse event, occurring in 4.7% of patients.
Potential Causes and Recommendations
- The cause of forearm pain in a patient taking Nexletol could be related to the medication's mechanism of action, which inhibits ATP-citrate lyase, reducing cholesterol production in the liver, but may also affect muscle tissue.
- Other potential causes of forearm pain, such as compartment syndrome or myofascial pain, should be considered and evaluated by a healthcare provider.
- In the meantime, patients can try over-the-counter pain relievers like acetaminophen (Tylenol) at standard doses (500-1000mg every 6 hours, not exceeding 3000mg daily) for temporary relief.
- Applying ice for 15-20 minutes several times daily and gentle stretching may also help alleviate forearm pain.
- It is essential to stay hydrated and avoid strenuous forearm activities to minimize discomfort while awaiting medical evaluation.
Importance of Medical Evaluation
- A healthcare provider may recommend blood tests to check for muscle enzyme elevation (CK levels) and adjust the dosage or consider alternative cholesterol-lowering medications if the pain persists or worsens.
- Regular monitoring and follow-up with a healthcare provider are crucial to ensure the safe and effective use of Nexletol and to address any potential side effects, including forearm pain.