Recommended Dosage for Foracit (Ciprofloxacin or Ofloxacin)
For ofloxacin, the standard adult dose is 200-400 mg orally every 12 hours, with specific dosing based on the type of infection being treated. 1
Ofloxacin Dosing
Adult Dosing
- For uncomplicated urinary tract infections (UTIs):
- 200 mg orally every 12 hours for 3 days (E. coli or K. pneumoniae) or 7 days (other pathogens) 1
- For complicated UTIs:
- 200 mg orally every 12 hours for 10 days 1
- For acute, uncomplicated gonorrhea:
- For nongonococcal cervicitis/urethritis due to C. trachomatis:
- 300 mg orally every 12 hours for 7 days 1
- For pelvic inflammatory disease:
- 400 mg orally every 12 hours for 10-14 days 1
- For prostatitis:
- 300 mg orally every 12 hours for 6 weeks 1
Dosing in Special Populations
- For patients with renal impairment:
- For patients with severe liver disorders:
- Maximum dose should not exceed 400 mg per day 1
Ciprofloxacin Dosing
Adult Dosing
- For urinary tract infections:
- 250-500 mg orally every 12 hours 2
- For uncomplicated gonorrhea:
- 500 mg orally as a single dose 2
- For systemic infections:
- 500 mg orally every 12 hours 2
- For intravenous administration:
- 400 mg IV every 12 hours 2
Pediatric Dosing (when necessary)
- Oral administration:
- 10-20 mg/kg/dose PO every 12 hours (maximum 750 mg/dose) 2
- Intravenous administration:
- 10 mg/kg/dose IV every 8 or 12 hours (maximum 400 mg/dose) 2
Important Considerations
- Fluoroquinolones should be used judiciously to prevent development of resistance 2
- Antacids containing calcium, magnesium, or aluminum; sucralfate; divalent or trivalent cations; or multivitamins containing zinc should not be taken within 2 hours before or after taking ofloxacin 1
- Ofloxacin has almost 100% bioavailability with peak serum concentrations obtained 1-2 hours following oral dosing 3
- Both ciprofloxacin and ofloxacin are generally well-tolerated, with most common adverse effects being gastrointestinal complaints, headache, and dizziness 4, 5
- For topical applications (such as otitis externa), ofloxacin otic solution 0.3% can be administered once daily for 7 days 6
Clinical Pearls
- When treating gonorrhea, if chlamydial infection is not ruled out, add azithromycin 1g orally in a single dose or doxycycline 100 mg orally twice daily for 7 days 2
- For disseminated gonococcal infection, initial parenteral therapy is recommended with ceftriaxone, but ofloxacin 400 mg IV every 12 hours can be used as an alternative regimen 2
- Fluoroquinolones are contraindicated in children, pregnant women, and nursing mothers due to potential effects on developing cartilage 3
- Resistance patterns should be considered when selecting fluoroquinolones for empiric therapy 2