Dosage of Voltaren (Diclofenac) Gel When Applied Twice Daily
The recommended dose of Voltaren (diclofenac) topical gel is 2 pump actuations (40 mg diclofenac sodium) applied to each affected area twice daily. 1
Proper Application Instructions
- Apply Voltaren gel to clean, dry skin 1
- For first-time use, prime the pump by fully depressing it 4 times while holding the bottle upright (discard this portion) 1
- For each application, completely depress the pump twice to dispense the proper amount for one treatment area 1
- Apply the gel evenly around front, back, and sides of the affected area 1
- Wash hands completely after application 1
- Wait until the area is completely dry before covering with clothing or applying other substances (sunscreen, insect repellent, cosmetics, etc.) 1
- Avoid skin-to-skin contact between other people and the treated area until completely dry 1
Important Precautions
- Avoid showering/bathing for at least 30 minutes after application 1
- Do not apply to open wounds 1
- Avoid contact with eyes and mucous membranes 1
- Do not apply external heat or occlusive dressings to treated areas 1
- Use the lowest effective dosage for the shortest duration consistent with treatment goals 1
- Do not use combination therapy with diclofenac gel and oral NSAIDs unless the benefit outweighs the risk 1
Pharmacokinetic Considerations
- Diclofenac gel is efficiently absorbed through the skin, with peak plasma concentrations occurring in 1.5-2 hours 2
- Despite its relatively short elimination half-life in plasma (1.5 hours), diclofenac persists in target tissues 2
- The percutaneous absorption of diclofenac sodium is approximately 6% of the applied dose 3
- When applied topically, diclofenac can achieve therapeutic concentrations in target tissues while minimizing systemic exposure 4
Clinical Efficacy and Safety
- Topical diclofenac provides similar pain relief to oral diclofenac but with significantly fewer systemic side effects 4
- Topical diclofenac is associated with fewer gastrointestinal adverse effects compared to oral NSAIDs 4
- The most common side effect of topical diclofenac is mild skin irritation at the application site 4
- Diclofenac is metabolized in the liver and eliminated through urinary and biliary excretion 2
Common Pitfalls to Avoid
- Applying more than the recommended dose does not increase efficacy and may increase side effects 1
- Failing to wash hands after application can lead to unintended exposure to eyes or other sensitive areas 1
- Covering the treated area before it's completely dry can affect absorption and efficacy 1
- Using oral and topical NSAIDs simultaneously without medical supervision increases risk of adverse effects 1