What is the use of Flonase (fluticasone propionate)?

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Last updated: March 22, 2025View editorial policy

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From the Guidelines

Flonase (fluticasone propionate) is used to treat allergic rhinitis and nonallergic rhinitis, with a recommended dose of 1 spray per nostril every day for adults and children aged 4 years and older, as indicated in the clinical practice guideline: allergic rhinitis study 1. The primary use of Flonase is to alleviate symptoms such as sneezing, itching, and congestion associated with allergic rhinitis.

  • The standard dosing for Flonase is 1 spray per nostril daily for children aged 4 years and older, and 1-2 sprays per nostril daily for adults, as per the guidelines 1.
  • It is essential to use Flonase consistently to achieve optimal results, as it may take several days to reach full effectiveness.
  • Before using Flonase, prime the bottle by spraying 6 times away from your face, then gently shake the bottle, insert the tip into your nostril while blocking the other nostril, point toward the outer eye, and spray while breathing in gently.
  • Flonase works by reducing inflammation in nasal passages and blocking chemicals that trigger allergic reactions, as supported by the study on pharmacologic treatment of seasonal allergic rhinitis 1.
  • Common side effects of Flonase may include nasal irritation, headache, and nosebleeds, as reported in the clinical practice guideline: allergic rhinitis study 1.
  • If you have glaucoma, cataracts, or recent nasal surgery, it is crucial to consult your doctor before using Flonase, as recommended in the study on pharmacologic treatment of seasonal allergic rhinitis 1.
  • Flonase is available over-the-counter and should be stored at room temperature away from moisture, as indicated in the clinical practice guideline: allergic rhinitis study 1.

From the FDA Drug Label

INDICATIONS AND USAGE Fluticasone Propionate Nasal Spray, USP, is indicated for the management of the nasal symptoms of seasonal and perennial allergic and nonallergic rhinitis in adults and pediatric patients 4 years of age and older. The use of Fluticasone Propionate Nasal Spray, USP, also known as Flonase, is for the management of nasal symptoms of:

  • Seasonal allergic rhinitis
  • Perennial allergic rhinitis
  • Nonallergic rhinitis in adults and pediatric patients 4 years of age and older 2.

From the Research

Use of Flonase (fluticasone propionate)

  • Flonase (fluticasone propionate) is used to treat allergic rhinitis, including symptoms such as nasal congestion and post-nasal drip 3.
  • It is a type of intranasal corticosteroid that can be used alone or in combination with other medications, such as azelastine nasal spray, to provide greater efficacy in treating seasonal allergic rhinitis 3.
  • Fluticasone propionate has been shown to have a comparable efficacy to other intranasal corticosteroids, such as mometasone furoate, in treating allergic rhinitis 3.
  • The use of fluticasone furoate, a related medication, has been studied in various clinical trials, demonstrating its effectiveness in reducing nasal symptoms and improving quality of life in patients with allergic rhinitis 4, 5, 6, 7.
  • Fluticasone furoate has been shown to be effective in treating both nasal and ocular symptoms of allergic rhinitis, with a rapid onset of action and a favorable safety profile 6.
  • A fixed-dose combination of fluticasone furoate and oxymetazoline has been developed, which has been shown to be effective in relieving nasal congestion and reducing total nasal symptom scores in patients with allergic rhinitis 4, 7.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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