Mupirocin Ointment Dosage for Bacterial Skin Infections
For a 5-day course of mupirocin ointment applied twice daily (BOD), approximately 15 grams of mupirocin ointment is required for treating a bacterial skin infection.
Dosing Guidelines for Mupirocin Ointment
- Mupirocin 2% ointment should be applied to affected areas twice daily for 5 days 1
- Each application typically requires approximately 1.5 grams of ointment to adequately cover a standard-sized skin infection 2, 3
- For a twice-daily regimen over 5 days (10 total applications), approximately 15 grams of ointment would be needed 1, 4
Clinical Efficacy and Application
- Mupirocin is highly effective against Staphylococcus aureus (including MRSA) and most streptococci, which are the primary pathogens in bacterial skin infections 2, 3
- The ointment should be applied to clean, dry skin with a thin layer covering the entire affected area 4, 5
- Clinical studies show that mupirocin ointment achieves bacterial eradication in >90% of patients when used properly 2, 4
Treatment Duration Considerations
- The recommended standard duration for mupirocin treatment is 5 days 1
- Treatment should be extended if the infection has not improved within the initial 5-day period 1
- For recurrent infections, a 5-day decolonization regimen with twice-daily intranasal mupirocin may be considered in addition to topical treatment of the infection 1
Application Technique
- Apply a small amount (approximately 1.5 grams per application) directly to the affected area 3, 6
- Cover the entire infected area and surrounding 1-2 cm of healthy skin 4, 5
- Wash hands thoroughly before and after application to prevent spread of infection 1, 4
Common Pitfalls to Avoid
- Underdosing: Using too little ointment may result in treatment failure 4, 5
- Premature discontinuation: Complete the full 5-day course even if symptoms improve quickly 1
- Inadequate coverage: Ensure the entire affected area is covered with each application 4, 6
- Failure to address underlying causes: For recurrent infections, consider decolonization strategies and addressing predisposing factors 1