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Differential Diagnosis for Scaly Hypopigmented Macular Lesions that Fluoresce Under Woods Lamp

  • Single Most Likely Diagnosis
    • Pityriasis versicolor: This condition is characterized by scaly, hypopigmented or hyperpigmented macules that typically fluoresce under Wood's lamp due to the presence of Malassezia yeast. It's a common skin condition, especially in young adults, and the description closely matches its clinical presentation.
  • Other Likely Diagnoses
    • Vitiligo: Although vitiligo typically presents with non-scaly, depigmented patches, some forms can have a fine scale and may show a blue-white fluorescence under Wood's lamp. It's an autoimmune condition leading to loss of melanocytes.
    • Pityriasis alba: This is a mild, chronic, eczematous condition seen mainly in children, characterized by round or oval, faintly erythematous, scaly patches that may appear hypopigmented. It might show some fluorescence under Wood's lamp, though it's not a hallmark.
  • Do Not Miss Diagnoses
    • Tinea versicolor due to other fungi: While Malassezia is the most common cause, other fungi can cause similar lesions. Missing a treatable fungal infection could lead to unnecessary suffering and potential for spread or secondary infection.
    • Sarcoidosis: Though less common, sarcoidosis can present with skin lesions that might appear hypopigmented and could potentially fluoresce under certain conditions. It's a systemic disease that can affect multiple organs, making early diagnosis critical.
  • Rare Diagnoses
    • Idiopathic guttate hypomelanosis: This condition presents with small, discrete, hypopigmented macules, often on the extremities. While it doesn't typically fluoresce under Wood's lamp, it's a consideration in the differential for hypopigmented lesions.
    • Leprosy (Hansen's disease): In its early stages, leprosy can cause hypopigmented skin lesions. Though rare in many parts of the world, it's a critical diagnosis not to miss due to its potential for serious neurological and dermatological complications if left untreated.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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