Differential Diagnosis for Skin Itching of Labia Majora

• Single Most Likely Diagnosis
  • Eczema/Dermatitis: This is a common condition that can cause itching and inflammation in the genital area, including the labia majora. It can be triggered by irritants, allergens, or friction.
• Other Likely Diagnoses
  • Candidiasis (yeast infection): A fungal infection that can cause itching, redness, and discharge in the genital area.
  • Contact dermatitis: An allergic reaction or irritation caused by soaps, detergents, or other substances that come into contact with the skin.
  • Lichen sclerosis: A chronic skin condition that can cause itching, pain, and scarring in the genital area.
  • Psoriasis: A chronic skin condition that can cause itching, redness, and scaly patches in the genital area.
• Do Not Miss Diagnoses
  • Herpes simplex virus (HSV): A viral infection that can cause painful blisters and itching in the genital area. If left untreated, it can lead to complications such as neonatal herpes.
  • Syphilis: A bacterial infection that can cause itching, pain, and lesions in the genital area. If left untreated, it can lead to serious complications such as neurosyphilis and congenital syphilis.
  • Vulvar intraepithelial neoplasia (VIN): A precancerous condition that can cause itching, pain, and abnormal cell growth in the genital area. If left untreated, it can progress to invasive cancer.
• Rare Diagnoses
  • Lichen planus: A chronic skin condition that can cause itching, pain, and scarring in the genital area.
  • Vulvar vestibulitis: A condition that causes chronic pain and itching in the vulvar area, often associated with inflammation and scarring.
  • Neurological disorders (e.g., neuropathic itch): Certain neurological conditions, such as multiple sclerosis or peripheral neuropathy, can cause itching sensations in the genital area without any visible skin lesions.