From the Guidelines
The maximum dose of quinidine is 1500 mg per day. This recommendation is based on the guidelines for the management of patients with atrial fibrillation, as outlined in the European Heart Journal 1. The daily dosage of quinidine can range from 600 to 1500 mg, with potential adverse effects including torsade de pointes, GI upset, and enhanced AV nodal conduction 1. Key considerations for quinidine therapy include:
- Monitoring for QT interval prolongation and torsade de pointes
- Avoiding use in patients with infrequent and well-tolerated angina pectoris or dyspnea
- Warning patients about the use of non-cardiac drugs that can prolong the QT interval
- Adjusting doses based on patient factors, such as renal function and QT-interval response. It is essential to weigh the benefits and risks of quinidine therapy, particularly given the potential for serious adverse effects, and to consider alternative treatment options, such as amiodarone or dofetilide, if necessary 1.
From the Research
Maximum Dose of Quinidine
There are no research papers to assist in answering this question. The provided studies do not mention quinidine, but rather discuss other medications such as local anesthetics, ebastine, cetirizine, quetiapine, and their respective dosages and safety profiles 2, 3, 4, 5, 6.
- The studies focus on the maximum recommended doses of local anesthetics, the pharmacological properties and clinical efficacy of ebastine, the treatment of allergic disorders with cetirizine, the management of acute exacerbations of schizophrenia with quetiapine, and the safety of low doses of quetiapine for insomnia.
- None of the studies provide information on the maximum dose of quinidine.