What are the steps for interpreting an electrocardiogram (EKG)?

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Last updated: October 9, 2025View editorial policy

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Systematic Approach to ECG Interpretation

A systematic approach to ECG interpretation is essential for accurate diagnosis of cardiac conditions, requiring careful analysis of rate, rhythm, axis, intervals, and waveform morphology. 1

Step 1: Assess Heart Rate and Rhythm

  • Calculate heart rate by counting the number of large squares between consecutive R waves (300 divided by number of large squares) or by counting QRS complexes in a 6-second strip and multiplying by 10 1
  • Evaluate rhythm regularity by examining R-R intervals for consistency - regular rhythms have uniform spacing between QRS complexes 1
  • Identify the underlying rhythm (sinus, atrial, junctional, ventricular) based on P wave morphology and relationship to QRS complexes 2

Step 2: Analyze Intervals and Segments

  • Measure PR interval (normal 120-200 ms or 3-5 small squares) to assess atrioventricular conduction 1
  • Evaluate QRS duration (normal <120 ms or <3 small squares) to assess ventricular conduction 1
  • Calculate QT interval and correct for heart rate (QTc, normal <450 ms for men, <460 ms for women) to assess ventricular repolarization 1
  • Examine ST segments for elevation or depression that may indicate ischemia, injury, or other pathology 2

Step 3: Determine Electrical Axis

  • Examine leads I and aVF to quickly determine the quadrant of the axis 1
  • Normal axis is between -30° and +90° 1
  • Left axis deviation: positive in lead I, negative in aVF 2
  • Right axis deviation: negative in lead I, positive in aVF 2

Step 4: Analyze P Waves

  • Assess P wave morphology (normal: upright in I, II, aVF; biphasic in V1) 1
  • Evaluate P wave duration (<120 ms) and amplitude (<2.5 mm) 2
  • Look for abnormal P wave patterns suggesting atrial enlargement or ectopic atrial rhythms 2

Step 5: Analyze QRS Complexes

  • Examine QRS morphology in all leads for pathologic Q waves (>1 mm wide and >1/3 the height of the R wave) suggesting myocardial infarction 1
  • Assess R wave progression across precordial leads (R wave amplitude should increase from V1 to V4, then decrease toward V6) 2
  • Look for bundle branch blocks, characterized by QRS widening (>120 ms) and specific morphology patterns 2

Step 6: Evaluate ST Segments and T Waves

  • Assess ST segments for elevation or depression (measured at the J point) 2
  • Evaluate T wave morphology (normally upright in leads I, II, V3-V6; inverted in aVR; variable in III, aVL, aVF, V1, V2) 2
  • Look for ST-T wave patterns suggesting ischemia, injury, electrolyte abnormalities, or other pathology 2

Step 7: Look for Additional Features

  • Identify any U waves (small deflection after T wave) which may indicate hypokalemia, bradycardia, or other conditions 2
  • Assess for signs of chamber enlargement (P wave abnormalities, QRS voltage criteria) 2
  • Look for conduction abnormalities (PR prolongation, QRS widening) 2

Special Considerations

  • Age and gender affect normal ECG parameters (e.g., QT intervals are typically longer in women) 1
  • Certain medications can significantly alter ECG findings (e.g., antiarrhythmics, psychotropics) 1
  • Technical factors like electrode placement and filtering can affect ECG appearance and interpretation 2
  • Computerized ECG interpretations should always be verified by a qualified physician, as automated algorithms have limitations in diagnostic accuracy 1, 3

Common Pitfalls to Avoid

  • Relying solely on computer interpretation without physician verification can lead to diagnostic errors 4
  • Failing to use a systematic approach may result in missed diagnoses 5
  • Interpreting ECG findings in isolation without considering clinical context can lead to inappropriate management decisions 4
  • Inadequate high-frequency characteristics in ECG machines can cause systematic underestimation of signal amplitude and smoothing of important features 4

References

Guideline

ECG Interpretation Guidelines

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

ЭКГ Интерпретация и Рентгенографические Изображения

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

The Electrocardiogram: Still a Useful Tool in the Primary Care Office.

The Medical clinics of North America, 2019

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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