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Last updated: October 9, 2025View editorial policy

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Differential Diagnosis for Labia Swelling

Single Most Likely Diagnosis

  • Infections (e.g., vulvovaginitis, Bartholin gland abscess): This is often the most common cause of labia swelling due to bacterial, fungal, or viral infections. Symptoms can include redness, warmth, pain, and discharge.

Other Likely Diagnoses

  • Allergic reactions or contact dermatitis: Irritation from soaps, dyes, or other substances can cause an allergic reaction leading to swelling and discomfort.
  • Trauma or injury: Direct injury to the labia can cause swelling, pain, and bruising.
  • Cysts or abscesses: Benign cysts or abscesses in the labia can cause localized swelling.
  • Sexually transmitted infections (STIs): Certain STIs, like herpes or syphilis, can cause labial swelling among other symptoms.

Do Not Miss Diagnoses

  • Necrotizing fasciitis: A rare but life-threatening infection that can cause severe swelling, pain, and necrosis of the tissue. Early recognition and treatment are crucial.
  • Malignancy (e.g., vulvar cancer): Although rare, any persistent or unexplained swelling should be evaluated for the possibility of cancer.
  • Deep vein thrombosis (DVT): Swelling in one leg or labia could be a sign of a DVT, which requires immediate medical attention to prevent pulmonary embolism.

Rare Diagnoses

  • Lymphogranuloma venereum (LGV): A rare STI that can cause swelling and other symptoms in the genital area.
  • Behçet's disease: A rare condition that can cause genital ulcers and swelling among other systemic symptoms.
  • Crohn's disease or ulcerative colitis: These inflammatory bowel diseases can rarely cause genital manifestations, including swelling.
  • Sarcoidosis: A systemic disease that can rarely affect the genital area, causing swelling or other symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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