What to do for a blister or swelling around a percutaneous endoscopic gastrostomy (PEG) tube?

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Last updated: October 9, 2025View editorial policy

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Management of Blister or Swelling Around PEG Tube

For blisters or swelling around a PEG tube, protect the skin with zinc oxide-based products, clean the area daily with antimicrobial cleanser, and check for proper tube positioning to prevent further complications. 1

Assessment and Initial Management

  • Inspect the site for signs of infection (redness beyond 5mm, pain, exudate), leakage of gastric contents, or excessive granulation tissue 1
  • Clean the affected area at least once daily using an antimicrobial cleanser to prevent infection and promote healing 2
  • Apply a barrier film, paste or cream containing zinc oxide to protect the surrounding skin from gastric acid damage 1
  • Use foam dressings rather than gauze to reduce local skin irritation, as foam lifts drainage away from the skin while gauze can contribute to skin maceration 1, 2

Management of Specific Complications

For Peristomal Leakage:

  • Apply zinc oxide-based skin protectants to minimize skin breakdown due to leakage 1
  • Consider starting proton pump inhibitors to decrease leakage by minimizing gastric acid secretion 1
  • For fungal infections associated with leakage, apply topical antifungal agents 1
  • Verify proper tension between the two bolsters, avoiding unnecessary tube movement or excessive pressure 1

For Excessive Granulation Tissue:

  • Apply topical antimicrobial agents under the fixation device 2
  • Consider foam or silver dressings over the affected area, changing only when significant exudate is present 2
  • For persistent granulation tissue, cauterization with silver nitrate applied directly onto the tissue may be effective 1
  • Alternative treatments include topical corticosteroid cream or ointment for 7-10 days combined with foam dressing to provide compression 1, 2

Tube Positioning and Maintenance

  • Check that the external fixation plate is properly positioned with free movement of at least 5mm to prevent pressure-related lesions 1
  • After initial healing (approximately one week), rotate the tube daily and move it inward at least once weekly (2-3cm) to prevent buried bumper syndrome 1
  • Return the tube to its initial position with 0.5-1cm free distance between the skin and external bolster after mobilization 1
  • For tubes with balloon retention devices, check the balloon volume content weekly to ensure it matches manufacturer's recommendations 1

When to Seek Advanced Care

  • For persistent infection despite local care, obtain a wound swab for microbiological examination and consider antibiotic treatment 1
  • If leakage is severe, consider temporarily delaying or stopping enteral nutrition, and implement gastric decompression 1
  • For refractory cases of leakage, removing the tube for 24-48 hours may permit slight spontaneous closure of the tract 1
  • If all measures fail to control leakage or infection, a new gastrostomy may need to be placed at a different location 1

Common Pitfalls to Avoid

  • Avoid replacing the tube with a larger-diameter tube, as this can result in an enlarged stoma tract with more leakage 1, 2
  • Do not use gauze directly on granulation tissue as it can adhere to the tissue and cause trauma upon removal 2
  • If the device is a gastrojejunostomy or has a jejunal extension, do not rotate it (only push in and out weekly) 1
  • Avoid excessive manipulation of granulation tissue, which can cause bleeding and pain 2, 3

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Management of Inflammatory Granulation Tissue

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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