From the Guidelines
The medical topic discussed in the PubMed article is the management and treatment of psoriasis in pediatric patients. This is based on the most recent and highest quality study available, which is the 2020 guidelines of care for the management and treatment of psoriasis in pediatric patients published in the Journal of the American Academy of Dermatology 1.
Key Points
- The guidelines were developed by a multidisciplinary workgroup of recognized psoriasis experts using an evidence-based model, with evidence obtained from a search of the PubMed and MEDLINE databases from January 2011 through December 31,2017 1.
- The guidelines evaluate the available evidence using a unified system called the Strength of Recommendation Taxonomy (SORT), which grades evidence based on the quality of methodology and the overall focus of the study 1.
- The guidelines provide clinical recommendations ranked based on the best available evidence, with recommendations based on consistent and good-quality patient-oriented evidence given the highest ranking 1.
- The guidelines discuss various treatment options for pediatric psoriasis, including biologics, non-biologic systemic agents, topical agents, and phototherapy, as well as the management of comorbidities such as psoriatic arthritis, inflammatory bowel disease, and cardiovascular disease 1.
Treatment Options
- The guidelines recommend the use of biologics such as adalimumab, etanercept, and ustekinumab for the treatment of moderate to severe pediatric psoriasis 1.
- The guidelines also discuss the use of non-biologic systemic agents such as methotrexate, cyclosporine, and acitretin, as well as topical agents such as topical corticosteroids and calcineurin inhibitors 1.
- Phototherapy, including narrowband ultraviolet B (UVB) and psoralen plus ultraviolet A (PUVA), is also discussed as a treatment option for pediatric psoriasis 1.
Management of Comorbidities
- The guidelines emphasize the importance of managing comorbidities such as psoriatic arthritis, inflammatory bowel disease, and cardiovascular disease in pediatric patients with psoriasis 1.
- The guidelines recommend regular monitoring for these comorbidities and referral to specialists as needed 1.
From the Research
Medical Topics Discussed in PubMed Articles
The medical topics discussed in the PubMed articles include:
- Drug development and therapeutic index [ 2 ]
- Smoking cessation and varenicline [ 3 ]
- Chronic kidney disease and denosumab [ 4 ]
- Supportive care in patients receiving chemotherapy [ 5 ]
- Antimicrobial therapies for chronic pain [ 6 ]
Specific Areas of Focus
These articles focus on specific areas such as:
- Characterization and optimization of safety and efficacy of drug candidates [ 2 ]
- Efficacy and safety of varenicline in smoking cessation [ 3 ]
- Fracture prevention and treatment of osteoporosis in chronic kidney disease [ 4 ]
- Management of side effects and complications in cancer treatment [ 5 ]
- Analgesic mechanisms of antimicrobial therapies for chronic pain [ 6 ]