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Last updated: October 10, 2025View editorial policy

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Differential Diagnosis for 36 year old female with left facial numbness and sinus congestion

  • Single most likely diagnosis
    • Sinusitis: This is the most likely diagnosis given the symptoms of sinus congestion and facial numbness, which can be referred pain from the sinuses.
  • Other Likely diagnoses
    • Migraine: Facial numbness can be a symptom of migraine, and sinus congestion can be a trigger or associated symptom.
    • Trigeminal Neuralgia: This condition causes sudden, severe facial pain, but can also cause numbness or tingling, and may be triggered by sinus pressure.
    • Dental issues: Dental problems such as an abscess or sinusitis related to a dental infection can cause facial numbness and sinus congestion.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Multiple Sclerosis: Although less likely, multiple sclerosis can cause facial numbness and should be considered, especially if other neurological symptoms are present.
    • Stroke or Transient Ischemic Attack (TIA): While rare in a 36-year-old, stroke or TIA can cause sudden facial numbness and should be ruled out immediately.
    • Cavernous Sinus Thrombosis: A rare but potentially life-threatening condition that can cause facial numbness, sinus congestion, and other neurological symptoms.
  • Rare diagnoses
    • Sarcoidosis: A rare autoimmune disease that can cause sinus congestion and facial numbness due to granulomatous inflammation.
    • Lyme disease: A rare infectious disease that can cause facial numbness and other neurological symptoms, especially if left untreated.
    • Tolosa-Hunt syndrome: A rare condition that causes facial pain and numbness due to inflammation of the cavernous sinus or superior orbital fissure.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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