Polytrim (Polymyxin B Sulfate and Trimethoprim) Dosage for Superficial Eye Infections
For superficial eye infections, Polytrim (polymyxin B sulfate and trimethoprim) ophthalmic solution should be instilled as one drop in the affected eye(s) every three hours (maximum of 6 doses per day) for 7 to 10 days. 1, 2
Dosage Regimen
- Instill one drop in the affected eye(s) every three hours 1
- Maximum of 6 doses per day 2
- Continue treatment for a period of 7 to 10 days 1, 2
- Same dosage regimen applies to both adults and pediatric patients over two months of age 2
Clinical Efficacy
- Polytrim has been shown to be safe and effective for the treatment of bacterial conjunctivitis 3
- Clinical studies have demonstrated high cure rates (84%) after completion of therapy 4
- The combination of trimethoprim with polymyxin B provides broad-spectrum coverage against both gram-positive and gram-negative pathogens 5
- Particularly effective against common ocular pathogens including Haemophilus influenzae and Streptococcus pneumoniae 4, 6
Treatment Considerations
- Topical antibiotic eye drops are the preferred method of treatment for most superficial eye infections as they achieve high tissue levels 7
- Ocular ointments generally have lower penetration into the cornea compared to solutions, but may be useful at bedtime in less severe cases 7
- For more severe infections (deep stromal involvement or large infiltrates), more aggressive treatment regimens may be necessary 7
- Fluoroquinolones are an alternative treatment option, particularly for more severe infections 7
Monitoring and Follow-up
- Patients should be evaluated for clinical response during treatment 7
- Signs of improvement include reduced pain, decreased discharge, lessened eyelid edema, and reduced conjunctival injection 7
- If no improvement is observed within 48 hours, consider modifying therapy 7
Common Pitfalls to Avoid
- Avoid prolonged use of topical antibiotics beyond the recommended duration as it may lead to antibiotic resistance 7
- Most antibiotic eye drops should not be tapered below 3 to 4 times a day as low doses are subtherapeutic and may increase the risk of developing resistance 7
- Avoid wearing contact lenses during treatment of eye infections 8
- Avoid delaying treatment, as early intervention leads to better outcomes 8
Polytrim represents an effective treatment option for superficial eye infections, providing broad-spectrum coverage with a convenient dosing schedule and good patient tolerability 3, 6.