Amoxicillin Dosage for 9.56kg 8-Month-Old Infant
For an 8-month-old infant weighing 9.56kg, the recommended dose of Amoxil (amoxicillin) 125mg/5ml is 45 mg/kg/day divided into two doses, which equals approximately 215mg twice daily (8.6ml of the 125mg/5ml suspension twice daily). 1
Dosing Rationale
- For infants ≥3 months (12 weeks) of age weighing less than 40kg, the FDA-approved dosage for mild to moderate infections is 25 mg/kg/day divided every 12 hours or 20 mg/kg/day divided every 8 hours 1
- For severe infections or lower respiratory tract infections, the recommended dosage increases to 45 mg/kg/day divided every 12 hours or 40 mg/kg/day divided every 8 hours 1
- The higher dose (45 mg/kg/day) is preferred for respiratory infections to ensure adequate coverage against potentially resistant Streptococcus pneumoniae 2
Calculation for 9.56kg Child
- At 45 mg/kg/day divided twice daily: 9.56kg × 45mg/kg ÷ 2 doses = 215mg per dose
- Using 125mg/5ml suspension: 215mg × (5ml/125mg) = 8.6ml per dose
- This dose should be administered twice daily (every 12 hours) 1
Duration of Therapy
- Treatment should be continued for a minimum of 48 to 72 hours beyond the time that the patient becomes asymptomatic 1
- For respiratory infections, a 10-day course is typically recommended, especially for infections caused by Streptococcus pyogenes to prevent acute rheumatic fever 1
- Recent evidence suggests that shorter courses (5 days) may be as effective as longer courses (10 days) for uncomplicated community-acquired pneumonia in children 3
Administration Guidelines
- Amoxicillin should be taken at the start of a meal to minimize gastrointestinal intolerance 1
- The oral suspension should be shaken well before each use 1
- After reconstitution, the suspension must be discarded after 14 days 1
- Refrigeration is preferable but not required for the reconstituted suspension 1
Monitoring and Follow-up
- Clinical improvement should be expected within 48-72 hours of starting appropriate therapy 2
- If no improvement occurs within this timeframe, consider alternative diagnoses or resistant organisms 4
- For children with respiratory infections, evaluate clinical response within 48-72 hours of initiating therapy 4
Special Considerations
- For infants with renal impairment, dose adjustments may be necessary 1
- If the infant has a history of penicillin allergy, alternative antibiotics should be considered 2
- For more severe infections or in areas with high antibiotic resistance, higher doses or alternative antibiotics may be warranted 2, 4