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Last updated: October 11, 2025View editorial policy

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Differential Diagnosis for Lower Extremity Burning Pain

Single Most Likely Diagnosis

  • Diabetic Neuropathy: This is a common cause of bilateral lower extremity burning pain, especially in patients with a history of diabetes. The pain is often symmetrical and can be accompanied by other symptoms such as numbness and tingling.

Other Likely Diagnoses

  • Peripheral Artery Disease (PAD): PAD can cause burning pain in the lower extremities, especially during exercise or at night. The pain is often relieved by rest.
  • Chronic Venous Insufficiency: This condition can cause burning pain, swelling, and skin changes in the lower extremities due to poor blood flow.
  • Fibromyalgia: While not exclusively a lower extremity condition, fibromyalgia can cause widespread pain, including burning pain in the legs.
  • Vitamin Deficiency (B12): A deficiency in vitamin B12 can cause neurological symptoms, including burning pain in the lower extremities.

Do Not Miss Diagnoses

  • Deep Vein Thrombosis (DVT): DVT can cause severe, burning pain in one leg, and it is essential to diagnose and treat promptly to prevent pulmonary embolism.
  • Compartment Syndrome: This is a medical emergency that can cause severe, burning pain in the lower extremities due to increased pressure within the muscle compartments.
  • Infection (Cellulitis or Abscess): Infections can cause burning pain, redness, and swelling in the lower extremities, and it is crucial to diagnose and treat promptly to prevent serious complications.

Rare Diagnoses

  • Erythromelalgia: A rare disorder that causes burning pain, heat, and redness in the hands and feet.
  • Complex Regional Pain Syndrome (CRPS): A rare condition that can cause severe, burning pain in one limb after an injury or trauma.
  • Amyloidosis: A rare condition that can cause burning pain in the lower extremities due to the deposition of abnormal proteins in the nerves.
  • Heavy Metal Poisoning: Exposure to heavy metals like arsenic or lead can cause burning pain in the lower extremities, among other symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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