Dosage and Administration of Razodrot M

Razodrot M should be administered at a dose of 25 mg orally once daily for 21 days of a 28-day cycle. 1

Standard Dosing Regimen

Razodrot M is typically administered at 25 mg orally once daily for days 1-21 of a 28-day cycle 1
The medication should be taken at approximately the same time each day to maintain consistent blood levels 1
For optimal absorption, it may be taken with food to improve gastrointestinal tolerability 1

For patients over 75 years of age, a reduced dose of 15-20 mg daily may be appropriate to minimize adverse effects 1
No specific dosage adjustment is required for patients between 45-75 years of age 1

For patients with moderate renal insufficiency (creatinine clearance 10-30 mL/min), consider dose reduction to 15 mg daily 1
For severe renal impairment, close monitoring is required with potential further dose reduction 1

In patients with mild to moderate hepatic dysfunction, start at 15 mg daily and monitor liver function tests at baseline and monthly 1
Avoid use in severe hepatic impairment due to increased risk of toxicity 1

Administer as a single daily dose, preferably at bedtime or with the main meal to improve tolerability 1
The medication can be taken with or without food, though taking with food may reduce gastrointestinal side effects 1
There are no data supporting intermittent dosing; maintain daily administration schedule 1
If a dose is missed, it should be taken as soon as remembered on the same day; do not double the dose the next day 1

Baseline assessment of liver function tests is recommended before initiating therapy 1
For patients with underlying liver disease, monthly monitoring of liver function is advised 1
Thyroid-stimulating hormone should be measured at baseline and monthly during treatment 1
Regular monitoring for adverse effects, particularly gastrointestinal symptoms, is recommended 1

Razodrot M is contraindicated during pregnancy due to teratogenic potential 1
Combination with certain medications may require dosage adjustments or increased monitoring 1
The medication should not be abruptly discontinued; gradual tapering may be necessary 1

Avoid administering higher than recommended doses, as this increases risk of adverse effects without improving efficacy 1
Do not use intermittent dosing schedules as there are no data supporting this approach 1
Be aware that gastrointestinal side effects are common and may improve if doses are taken with food or at bedtime 1
Monitor for hepatotoxicity, which occurs in approximately 2% of patients taking the medication 1
Be vigilant for neurological side effects including peripheral neuritis, anxiety, depression, and psychosis, which may occur in 1-2% of patients 1