How to administer an 80mg IV bolus of Protonix (pantoprazole)?

How to Administer an 80mg IV Bolus of Protonix (Pantoprazole)

For an 80mg IV bolus of pantoprazole (Protonix), reconstitute with 10mL of 0.9% Sodium Chloride Injection per vial (two 40mg vials) to a concentration of 4mg/mL, and administer intravenously over at least 2 minutes.

Preparation Instructions for 80mg IV Bolus

• Use two 40mg vials of Pantoprazole Sodium for Injection 1
• For each vial, reconstitute with 10mL of 0.9% Sodium Chloride Injection, USP, to achieve a concentration of approximately 4mg/mL 1
• Visually inspect the reconstituted solution for particulate matter and discoloration prior to and during administration 1
• The reconstituted solution may be stored for up to 24 hours at room temperature prior to administration and does not need to be protected from light 1

Administration Technique

• Administer the total volume from both vials (20mL total) intravenously over a period of at least 2 minutes 1
• Administer through a dedicated line or through a Y-site 1
• Flush the intravenous line before and after administration with either 5% Dextrose Injection, USP, 0.9% Sodium Chloride Injection, USP, or Lactated Ringer's Injection, USP 1

Important Compatibility Considerations

• Pantoprazole is compatible with the following solutions when administered through a Y-site: 5% Dextrose Injection, USP, 0.9% Sodium Chloride Injection, USP, or Lactated Ringer's Injection, USP 1
• Midazolam HCl has been shown to be incompatible with Y-site administration of Pantoprazole Sodium for Injection 1
• Pantoprazole may not be compatible with products containing zinc 1
• If administered through a Y-site, immediately discontinue the infusion if precipitation or discoloration occurs 1

Clinical Considerations

• The 80mg IV bolus dose is typically used for pathological hypersecretory conditions including Zollinger-Ellison Syndrome 1, 2
• For standard GERD treatment, the typical dose is 40mg IV, not 80mg 1
• Monitor for potential adverse effects, though pantoprazole is generally well tolerated in both short and long-term administration 3
• Pantoprazole shows linear pharmacokinetics after both IV and oral administration with a serum elimination half-life of about 1.1 hours 4

Storage Considerations

• Do not freeze either the reconstituted or diluted solutions 1
• The reconstituted solution does not need to be protected from light 1

By following these specific preparation and administration instructions, you can safely deliver an 80mg IV bolus dose of pantoprazole to your patient.