Oxacillin Compatibility with 5% Dextrose Solution (D5)
Yes, oxacillin is compatible with 5% dextrose solution (D5) and can be administered in this diluent. According to the FDA drug label, oxacillin maintains stability in 5% dextrose in water for up to 6 hours at room temperature (25°C) 1.
Stability Information
- Oxacillin has documented stability in 5% dextrose solution with the following parameters:
Administration Guidelines
- For intravenous administration via infusion:
- Reconstitute oxacillin first using Sterile Water for Injection or Sodium Chloride Injection 1
- Then dilute to the appropriate concentration in 5% dextrose solution 1
- The concentration should be between 0.5-2 mg/mL when using 5% dextrose as the diluent 1
- Administer the complete dose before the 6-hour stability window expires 1
Important Considerations
- The drug concentration and infusion rate should be adjusted so the total dose is administered before stability is compromised 1
- Do not physically mix oxacillin with other medications in the same solution; administer other agents separately 1
- Inspect the solution visually for particulate matter and discoloration prior to administration 1
- For severe staphylococcal infections, therapy with oxacillin should be continued for at least 14 days 1
Potential Pitfalls
- Exceeding the 6-hour stability window at room temperature may result in decreased antimicrobial efficacy 1
- Using concentrations outside the recommended range (0.5-2 mg/mL) in D5 may affect stability 1
- Monitor for thrombophlebitis, particularly in elderly patients receiving intravenous oxacillin 1
- Do not add supplementary medication directly to oxacillin solution 1
By following these guidelines, oxacillin can be safely and effectively administered in 5% dextrose solution while maintaining appropriate antimicrobial activity.