What is the significance of a 3mm nodule located in the fat anterior to the psoas muscle, below the lower pole of the left kidney, which appeared 1.5 months after surgery for a 1.3cm T1a chromophobe renal cell carcinoma (RCC)?

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Differential Diagnosis for 3mm Nodule

  • Single most likely diagnosis
    • Post-surgical granuloma or scar: This is the most likely diagnosis given the nodule's appearance after surgery and its maturation over time. The location in the fat anterior to the psoas, a common site for surgical trauma, further supports this diagnosis.
  • Other Likely diagnoses
    • Lipoma or other benign fat lesion: The nodule's small size and location in the fat suggest a benign lesion such as a lipoma. However, the fact that it was not present before surgery and appeared afterwards makes this less likely.
    • Reactive lymph node: Although less common in this location, a reactive lymph node could be considered, especially given the recent surgical history.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Metastasis from the chromophobe RCC: Although the primary tumor was small (T1a) and of a relatively favorable histology, metastasis to the fat or soft tissues is a possibility that should not be overlooked.
    • Recurrence of chromophobe RCC: Local recurrence, although less likely given the small size of the primary tumor and the time frame, is a critical diagnosis not to miss.
  • Rare diagnoses
    • Soft tissue sarcoma: This would be an unusual occurrence, especially in the context of recent surgery, but it is a diagnosis that should be considered in the differential due to its potential severity.
    • Other rare soft tissue tumors (e.g., schwannoma, neurofibroma): These are less likely but should be kept in mind, especially if the nodule's characteristics do not fit more common diagnoses.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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