What health screenings and labs are recommended for a 45-year-old male for preventive care and wellness?

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Last updated: October 12, 2025View editorial policy

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Health Screenings and Labs Recommended for a 45-Year-Old Male

For a 45-year-old male, colorectal cancer screening should begin at age 45 using one of several testing options, including annual fecal immunochemical testing (FIT), colonoscopy every 10 years, or other approved screening methods. 1

Cancer Screenings

Colorectal Cancer Screening

  • Begin screening at age 45 with one of the following options 2, 1:
    • Annual high-sensitivity guaiac fecal occult blood testing (FOBT) or fecal immunochemical testing (FIT)
    • Flexible sigmoidoscopy every 5 years
    • Colonoscopy every 10 years
    • CT colonography every 5 years
    • Multitarget stool DNA test every 3 years
    • Double-contrast barium enema every 5 years

Prostate Cancer Screening

  • Discuss prostate cancer screening options at age 45, especially for men at higher risk (African American men or those with a family history of prostate cancer) 2
  • Screening involves PSA testing and possibly digital rectal examination 1
  • Shared decision-making approach recommended to weigh potential benefits against harms of screening 2, 1

Cardiovascular Health Screenings

Blood Pressure Screening

  • Regular blood pressure measurement at each healthcare visit 3
  • Target: less than 120/80 mm Hg 3

Lipid Screening

  • Recommended for men 40 to 75 years of age 2, 3
  • Includes total cholesterol and HDL cholesterol measurements 2
  • Can be performed on non-fasting samples 2
  • Abnormal results should be confirmed with repeat testing 2
  • Screening interval typically every 5 years for normal results, more frequent for borderline results 2

Diabetes Screening

  • Recommended for adults 35 to 70 years who are overweight or obese (BMI ≥25) 4
  • Testing options include 5:
    • Fasting plasma glucose (≥126 mg/dL indicates diabetes)
    • Hemoglobin A1C (≥6.5% indicates diabetes)
    • 2-hour oral glucose tolerance test (≥200 mg/dL indicates diabetes)
  • Repeat testing every 3 years if results are normal 4

General Health Assessment

  • Calculate BMI to assess weight status 3
  • Assess tobacco and alcohol use 3
  • Evaluate diet and exercise habits 3
  • Screen for HIV and other sexually transmitted infections based on risk factors 3
  • Review immunization status and update as needed 3

Important Considerations

  • Risk factors such as family history, smoking status, and existing health conditions may warrant earlier or more frequent screening 1, 3
  • All positive results on non-colonoscopy colorectal screening tests should be followed up with timely colonoscopy 1
  • Lifestyle counseling regarding diet, exercise, and smoking cessation is an essential component of preventive care 3, 6

Common Pitfalls to Avoid

  • Delaying colorectal cancer screening beyond age 45, as guidelines have recently lowered the recommended starting age from 50 to 45 1
  • Failing to repeat abnormal lipid or glucose test results for confirmation before making a diagnosis 2, 5
  • Not considering individual risk factors that might necessitate earlier or more intensive screening 1
  • Overlooking the importance of shared decision-making for prostate cancer screening 2

References

Guideline

Cancer Screening Guidelines for Adults

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

The Adult Well-Male Examination.

American family physician, 2018

Research

Diabetes Mellitus: Screening and Diagnosis.

American family physician, 2016

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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