Primary Myelofibrosis: This condition often presents with elevated platelet counts due to bone marrow fibrosis leading to extramedullary hematopoiesis, and elevated alkaline phosphatase can be seen due to bone involvement or liver dysfunction secondary to the disease.

Polycythemia Vera: A myeloproliferative neoplasm that can cause an increase in platelet count. Elevated alkaline phosphatase may be seen in the context of hepatomegaly or bone metastasis.
Reactive Thrombocytosis: This condition can occur in response to inflammation, infection, or malignancy, leading to elevated platelet counts. Alkaline phosphatase can be elevated in conditions like bone fractures, osteomalacia, or liver diseases that may coexist.
Bone Metastasis: Certain cancers (e.g., prostate, breast) can metastasize to bone, leading to elevated alkaline phosphatase. The body's response to the cancer can also lead to elevated platelets.

Hodgkin Lymphoma: Although less common, Hodgkin lymphoma can present with elevated platelets and alkaline phosphatase, particularly if there is significant bone marrow involvement or liver dysfunction.
Abdominal Aortic Aneurysm: Inflammation and repair processes in abdominal aortic aneurysms can lead to reactive thrombocytosis, and if the aneurysm involves or compresses nearby structures (like the liver or bones), alkaline phosphatase can be elevated.

Osteosarcoma: A rare bone cancer that can cause elevated alkaline phosphatase due to bone turnover. Paraneoplastic syndromes associated with osteosarcoma can lead to elevated platelet counts.
Paget's Disease of Bone: A chronic bone disorder that can result in elevated alkaline phosphatase. While not typically associated with thrombocytosis, the disease's impact on bone and potential for secondary complications could rarely lead to elevated platelets.