From the Research
Joint Subluxation and Sickle Cell Crisis
- There is limited direct evidence on the relationship between joint subluxation and sickle cell crisis. However, studies have shown that sickle cell disease can cause various orthopedic manifestations, including osteonecrosis, osteomyelitis, septic arthritis, and bone infarction 1, 2.
- Sickle cell disease is characterized by vascular occlusive episodes, which can lead to bone and joint complications, including avascular necrosis of the femoral head and humeral head 1, 2.
- Joint subluxation or dislocation is not explicitly mentioned as a common complication of sickle cell disease in the provided studies. However, one study reported a pooled proportion of dislocation of 4% (95%CI: 2-7%, I2 = 66%) in patients with sickle cell disease who underwent total hip arthroplasty 3.
- The relationship between joint subluxation and sickle cell crisis is not well-established, and more research is needed to understand the potential link between these two conditions.
Sickle Cell Crisis and Orthopedic Complications
- Sickle cell crisis can occur in patients with sickle cell disease, and it is often associated with severe pain and end-organ damage 4.
- Orthopedic complications, such as osteonecrosis and osteomyelitis, can increase the risk of sickle cell crisis in patients with sickle cell disease 1, 2.
- The pooled proportion of sickle cell disease crisis after total hip arthroplasty was reported to be 9% (95%CI, 5-14%, I2 = 61%) in one study 3.
- The relationship between sickle cell crisis and orthopedic complications is complex, and further research is needed to understand the underlying mechanisms and risk factors.
Adhesion Molecules and Sickle Cell Disease
- The expression of adhesion molecules on white blood cells may play a role in the pathogenesis of sickle cell disease, including the development of vaso-occlusive crises 5.
- High expression of certain adhesion molecules, such as alphaMbeta2 integrin and l-selectin, has been associated with severe manifestations of sickle cell disease, including sickle cell crisis 5.
- The relationship between adhesion molecules and joint subluxation in sickle cell disease is not well-established, and further research is needed to understand the potential link between these factors.