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Last updated: October 13, 2025View editorial policy

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Differential Diagnosis for a Painless, Immobile, Non-Cystic Lump on the Thigh

Single Most Likely Diagnosis

  • Lipoma: A common, benign tumor composed of fat tissue. It is often painless, immobile, and can be found in various parts of the body, including the thigh. Lipomas are usually non-cystic and can grow to a considerable size.

Other Likely Diagnoses

  • Fibroma: A benign tumor of fibrous or connective tissue. It can present as a firm, painless lump and is generally immobile.
  • Hematoma: A collection of blood outside of blood vessels, which can occur due to trauma. Although it might initially be painful, an old hematoma can become painless and feel like a firm, immobile lump.
  • Scar tissue or keloid: Especially if there's a history of trauma or surgery, scar tissue can form a lump that is firm and non-tender.

Do Not Miss Diagnoses

  • Soft tissue sarcoma: Although rare, sarcomas are malignant tumors that originate from soft tissues like muscles, fat, and connective tissues. They can present as a painless lump and are critical to diagnose early due to their potential for aggressive behavior and metastasis.
  • Lymphoma: Certain types of lymphoma can manifest as a lump in the thigh, especially if there's involvement of lymph nodes in the area.

Rare Diagnoses

  • Neurofibroma: A benign nerve sheath tumor that can occur in the thigh. It's more commonly associated with neurofibromatosis type 1 but can occur sporadically.
  • Desmoid tumor (aggressive fibromatosis): A rare, benign but locally aggressive tumor that can occur in the thigh. It's known for its potential to cause significant morbidity due to local invasion.
  • Myositis ossificans: A condition where there's heterotopic ossification of soft tissues, often following trauma. It can present as a firm, painless lump in the muscle of the thigh.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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