How to safely discontinue Rexulti (brexpiprazole)?

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How to Safely Discontinue Rexulti (Brexpiprazole)

When discontinuing Rexulti (brexpiprazole), a gradual taper is recommended with dose reduction of 25% every 1-2 weeks to minimize withdrawal symptoms and ensure patient safety. 1

Recommended Tapering Protocol

  • Begin with patient education about the risks of abrupt discontinuation and benefits of gradual tapering 1
  • Implement a structured tapering schedule reducing the total daily dose by approximately 25% every 1-2 weeks 1
  • For patients on standard doses (2-4 mg/day for schizophrenia or 2 mg/day for depression), consider this sample schedule:
    • Weeks 1-2: Reduce dose by 25% of original dose
    • Weeks 3-4: Reduce to 50% of original dose
    • Weeks 5-6: Reduce to 25% of original dose
    • Weeks 7-8: Complete discontinuation 1

Monitoring During Tapering

  • Assess for withdrawal symptoms at each follow-up visit 1
  • Watch for both acute withdrawal symptoms (anxiety, insomnia, restlessness) and protracted withdrawal symptoms 1
  • Monitor for potential return of underlying symptoms, as brexpiprazole is used for schizophrenia and as adjunctive therapy for major depressive disorder 2, 3

Special Considerations

  • Patients with schizophrenia require particularly careful monitoring during discontinuation as relapse risk is significant (38.5% relapse rate observed in clinical trials when medication is stopped) 4
  • For patients taking brexpiprazole as adjunctive therapy for depression, consider whether the antidepressant therapy should be adjusted during the taper 3, 5
  • Patients earlier in their disease course may respond differently to medication changes than those with longer-standing illness 5

Adjunctive Strategies During Discontinuation

  • Consider non-pharmacological interventions to manage symptoms during taper, such as cognitive-behavioral therapy and relaxation techniques 1
  • Avoid concurrent use of other CNS depressants during the taper period to minimize complications 1
  • Address underlying reasons for discontinuation and provide appropriate alternative treatments if needed 1

Common Pitfalls to Avoid

  • Avoid abrupt discontinuation due to risk of withdrawal symptoms 1
  • Don't overlook the need for continued monitoring after complete discontinuation, as delayed withdrawal effects can occur 1
  • Remember that brexpiprazole has a unique receptor binding profile with effects on multiple neurotransmitter systems (dopamine D2, serotonin 5-HT1A, 5-HT2A), so withdrawal may manifest in various ways 2, 6

When to Seek Additional Help

  • If severe withdrawal symptoms occur despite gradual tapering, consider slowing the taper further 1
  • If symptoms of the underlying condition (schizophrenia or depression) worsen significantly during tapering, consult with a psychiatrist to reassess the treatment plan 2, 3
  • For patients with complex comorbidities or on multiple psychotropic medications, consider referral to a specialist for medication management during discontinuation 1

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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