Differential Diagnosis for Dysuria in a 60yo Woman after Paxlovid for COVID
Single Most Likely Diagnosis
- Urinary Tract Infection (UTI): Given the patient's age and the onset of symptoms after taking Paxlovid, a UTI is a common and likely cause of dysuria. The use of antibiotics or antivirals can sometimes alter the normal flora, predisposing to infections.
Other Likely Diagnoses
- Vaginal Atrophy: This condition is common in postmenopausal women and can cause dysuria due to the thinning and drying of the vaginal walls. The stress of a recent illness like COVID-19 might exacerbate symptoms.
- Medication-Induced Cystitis: Paxlovid, like other medications, can irritate the bladder, leading to symptoms of cystitis, including dysuria.
- Dehydration: Inadequate fluid intake, especially during or after an illness, can lead to concentrated urine, which might cause dysuria.
Do Not Miss Diagnoses
- Kidney Stones: Although less common, kidney stones can cause severe dysuria and must be considered, especially if the patient has a history of stones or if the pain is severe and radiates to the back.
- Interstitial Cystitis: This chronic condition can cause dysuria and should be considered if symptoms persist despite treatment for more common causes.
- Tubulointerstitial Nephritis: An allergic reaction to medications, including Paxlovid, can cause this condition, leading to dysuria among other symptoms.
Rare Diagnoses
- Fungal Infections: In immunocompromised patients or those with diabetes, fungal infections of the urinary tract can occur, though they are less common.
- Genital Herpes: Reactivation of genital herpes can cause dysuria, especially if the patient has a history of the condition.
- Bladder Cancer: Although rare, new-onset dysuria in an older adult could be a symptom of bladder cancer, and thus, it should not be entirely ruled out without proper evaluation.