From the Research
GS-441524 oral administration can be as effective as injection for treating non-effusive (dry) FIP in cats, with a typical oral dosage ranging from 10-15 mg/kg given once daily for at least 84 days (12 weeks) 1. The exact dose depends on disease severity and individual response. Key points to consider when treating non-effusive FIP with GS-441524 include:
- Oral GS-441524 offers the advantage of being less stressful for both cats and owners compared to daily injections.
- For successful treatment, consistent administration is crucial, and the full treatment course must be completed even if symptoms improve earlier.
- Regular veterinary monitoring, including bloodwork, is recommended throughout treatment to assess response and adjust dosing if needed.
- The medication works by inhibiting viral replication of the feline coronavirus that causes FIP.
- While oral administration is generally effective for non-effusive FIP, cats with effusive (wet) FIP or neurological involvement may require higher doses or injectable forms for better drug distribution to affected tissues.
- Treatment should only be discontinued after consultation with a veterinarian to ensure complete viral clearance and prevent relapse. A recent study published in 2024 found that a shorter treatment duration of 42 days with oral GS-441524 can be considered equally effective as the recommended 84-day treatment in cats with FIP with effusion 1. However, it is essential to note that the effectiveness of GS-441524 oral administration may vary depending on the specific context and individual case, and treatment decisions should be made in consultation with a veterinarian. Other studies have also investigated the use of remdesivir and GS-441524 in treating FIP, including a study published in 2023 that found a combination of remdesivir and GS-441524 to be effective in treating cats with FIP 2, 3, 4. Additionally, a study published in 2022 found that orally administered GS-441524 achieves plasma levels greater than the established EC50 values, which are sustained over 24 hours 5. Overall, the current evidence suggests that GS-441524 oral administration can be an effective treatment option for non-effusive FIP in cats, but treatment decisions should be made on a case-by-case basis in consultation with a veterinarian.