What is the likelihood of cancer with a cerebrospinal fluid (CSF) analysis showing 75% lymphocytes, elevated total protein (49g/L), hypercholesterolemia (76g/dL), and adenosine deaminase (ADA) level of 13, in a patient with a serum protein level of 6.6g/dL?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: March 24, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Ascites Fluid Analysis

Single Most Likely Diagnosis

  • Tuberculous Peritonitis: The presence of 75% lymphocytes in the ascites fluid, along with an ADA (Adenosecleoside Deaminase) level of 13, is highly suggestive of tuberculous peritonitis. This condition is a common cause of ascites with a high lymphocyte count.

Other Likely Diagnoses

  • Malignancy-Related Ascites: Although the ADA level is not typically elevated in malignancy-related ascites, the presence of a high total protein level (49g/L) and a relatively low serum-ascites albumin gradient (SAAG) could be seen in cases of peritoneal carcinomatosis. However, the lymphocyte predominance and ADA level make this less likely.
  • Lymphoma: Similar to tuberculous peritonitis, lymphoma can cause ascites with a high lymphocyte count. However, the ADA level is typically not as elevated as in tuberculous peritonitis.

Do Not Miss Diagnoses

  • Spontaneous Bacterial Peritonitis (SBP): Although the fluid analysis does not show a high neutrophil count, SBP can present with a variety of cell counts, and it is essential to consider this diagnosis due to its high mortality rate if left untreated.
  • Peritoneal Carcinomatosis with Secondary Infection: In cases of peritoneal carcinomatosis, secondary infection can occur, leading to an elevated neutrophil count. However, the presence of 75% lymphocytes makes this less likely.

Rare Diagnoses

  • Chylous Ascites: The presence of a high total cholesterol level (7.6g/dL) could suggest chylous ascites, although this is typically associated with a milky appearance of the ascites fluid and a higher triglyceride level.
  • Eosinophilic Ascites: Although rare, eosinophilic ascites can occur in cases of eosinophilic gastroenteritis or other conditions. However, the presence of 75% lymphocytes makes this diagnosis unlikely.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.