What is the specific treatment for fever with generalized body aches, also known as pyrexia with myalgia (muscle pain)?

From the Guidelines

For fever with generalized body aches, paracetamol is recommended as the first-line treatment, as it can help alleviate symptoms such as fever and muscle pain, and should be taken only while symptoms are present, as advised by the most recent guidelines 1. When managing fever with generalized body aches, it is essential to prioritize the patient's comfort and hydration.

• Patients should be advised to drink fluids regularly to avoid dehydration, with a recommended intake of no more than 2 liters per day 1.
• Antipyretics should not be used solely to reduce body temperature, but rather to alleviate symptoms such as fever and muscle pain 1.
• Paracetamol is preferred over non-steroidal anti-inflammatory drugs (NSAIDs) for patients with COVID-19, and should be taken as needed to manage symptoms 1. It is crucial to monitor the patient's temperature and adjust treatment accordingly.
• If the temperature exceeds 103°F (39.4°C), persists beyond 3 days, or is accompanied by severe symptoms, medical attention should be sought immediately, as these symptoms could indicate a more serious condition requiring specific treatment 2.
• Symptomatic treatment of fever can be achieved with ibuprofen, but it is essential to follow the recommended dosage and frequency, such as 0.2 g per time, every 4-6 hours, but no more than 4 times in 24 hours, as stated in the guidelines for the diagnosis and treatment of 2019 novel coronavirus (2019-ncov) infected pneumonia 2.

From the FDA Drug Label

PURPOSE Pain reliever/fever reducer USES For Arthritis Pain label • temporarily relieves minor aches and pains due to: • minor pain of arthritis • muscular aches • backache • premenstrual and menstrual cramps • the common cold • headache • toothache • temporarily reduces fever USES For Muscle Aches & Pain label • temporarily relieves minor aches and pains due to: • muscular aches • backache • minor pain of arthritis • toothache • premenstrual and menstrual cramps • headache • the common cold • temporarily reduces fever

The specific treatment for fever with generalized body aches, also known as pyrexia with myalgia (muscle pain), is acetaminophen (PO), which can temporarily reduce fever and relieve minor aches and pains due to muscular aches [3] [4].

• Key benefits: temporarily reduces fever, relieves minor aches and pains due to muscular aches
• Important consideration: always follow the recommended dosage and consult a healthcare professional if symptoms persist or worsen.

From the Research

Treatment for Pyrexia with Myalgia

The treatment for fever with generalized body aches, also known as pyrexia with myalgia, typically involves the use of analgesic and antipyretic medications.

• Paracetamol (also known as acetaminophen) is a common first-line treatment for managing fever and mild-to-moderate pain in both children and adults 5, 6, 7, 8, 9.
• The recommended dose of paracetamol for fever and pain management is 15 mg/kg for children, which has been shown to be effective and safe 5.
• For adults, a dose of 1,000 mg of paracetamol has been used to treat fever, with some studies suggesting that a combination of paracetamol and ibuprofen may be more effective in certain cases, such as bacterial fever 6.
• Ibuprofen is another option for treating fever and pain, and has been shown to be effective in reducing temperature and pain in children younger than 2 years, with a similar safety profile to paracetamol 8.
• The choice of treatment may depend on the underlying cause of the fever, as well as individual patient factors, such as age and medical history 6, 8.

Mechanism of Action

• Both paracetamol and ibuprofen work by inhibiting the production of prostaglandins, which are chemicals in the body that cause fever and pain 9.
• Paracetamol has a complex mechanism of action, involving multiple pathways and receptors, which contributes to its analgesic and antipyretic effects 5, 7.
• Ibuprofen, on the other hand, is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins 9.

Safety and Efficacy

• Paracetamol is generally considered safe and effective when used as directed, but can cause liver damage if taken in excess or combined with alcohol 7.
• Ibuprofen is also generally safe and effective, but can cause gastrointestinal side effects, such as stomach upset and bleeding, especially when used in high doses or for extended periods 8, 9.
• The safety and efficacy of paracetamol and ibuprofen have been extensively studied, with numerous clinical trials and meta-analyses demonstrating their effectiveness in reducing fever and pain in both children and adults 5, 6, 8.