From the FDA Drug Label
In severe acne, minocycline may be useful adjunctive therapy.
The recommended tetracycline prescription for persistent acne is minocycline as an adjunctive therapy 1.
- Minocycline may be useful in the treatment of severe acne.
- It is not indicated as a primary treatment, but rather as an adjunctive therapy.
From the Research
For the treatment of persistent acne, minocycline is recommended at a dose of 50-100 mg, once or twice daily, due to its efficacy and relatively low resistance rate, as supported by the latest guidelines 2. The choice of tetracycline antibiotic for acne treatment depends on various factors, including the severity of the condition, patient medical history, and potential drug interactions.
- Tetracyclines like doxycycline and minocycline are commonly prescribed for acne, usually for 3-6 months.
- These medications work by reducing inflammation and killing bacteria that contribute to acne.
- Side effects may include photosensitivity, gastrointestinal upset, and rarely more serious effects.
- Tetracyclines should not be taken with dairy products, antacids, or iron supplements as these can reduce absorption.
- They're also contraindicated during pregnancy and in children under 8 years old. A study published in 2016 highlights the increasing threat of antibiotic resistance in acne treatment, emphasizing the need for responsible use of oral antibiotics and the importance of combining them with topical retinoids or benzoyl peroxide to minimize resistance 3. Another study from 2008 demonstrates the efficacy of subantimicrobial-dose doxycycline in treating moderate facial acne, with significant reductions in inflammatory lesions 4. However, minocycline remains a preferred option due to its high lipophilicity, anti-inflammatory action, and lower resistance rate compared to other tetracyclines, as noted in the 2010 study 2. It is essential to consult with a dermatologist or primary care physician to determine the most appropriate treatment regimen for individual cases of persistent acne, considering the latest guidelines and the patient's specific condition.