Can Ozempic (semaglutide) be used if left at room temperature for a week?

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Last updated: October 14, 2025View editorial policy

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Ozempic Storage at Room Temperature

Ozempic (semaglutide) can be safely used if left at room temperature for up to 56 days, as long as it has been stored between 59°F to 86°F (15°C to 30°C) and protected from light. 1

Storage Guidelines for Ozempic

  • After first use, Ozempic pens can be stored for 56 days at controlled room temperature (59°F to 86°F; 15°C to 30°C) or in a refrigerator (36°F to 46°F; 2°C to 8°C) 1
  • The medication should always be protected from excessive heat and sunlight, regardless of storage temperature, to prevent degradation 1
  • Prior to first use, Ozempic should be stored in a refrigerator between 36°F to 46°F (2°C to 8°C) to maintain maximum potency and shelf life 1
  • Do not freeze Ozempic and do not use Ozempic if it has been frozen 1

Important Considerations

  • Always visually inspect Ozempic before use - it should appear as a clear, colorless solution 1
  • If the solution appears cloudy, discolored, or contains particles, the medication should not be used 1
  • The pen cap should be kept on when not in use to protect the medication from light 1
  • Always remove and safely discard the needle after each injection and store the Ozempic pen without an injection needle attached 1

Stability of Biologics at Room Temperature

  • Biologics like Ozempic have undergone extensive stability testing by manufacturers to establish safe storage parameters 2
  • More concentrated medications generally maintain potency better than diluted ones when exposed to temperature variations 2
  • Studies have shown that the vast majority of thermolabile drugs maintain adequate stability at room temperature for acceptable periods of time 2
  • A comprehensive review of 246 products requiring refrigeration found that 87% had documented acceptable periods for room temperature excursions 3

Practical Advice

  • If your Ozempic has been at room temperature for exactly one week, it remains well within the 56-day room temperature stability window 1
  • Keep track of when the pen was first removed from refrigeration to ensure it's used within the 56-day period 1
  • If you're concerned about the appearance of the medication or if it has been exposed to temperatures above 86°F (30°C), it's best to obtain a replacement 1
  • Always use a new needle for each injection to maintain sterility 1

By following these guidelines, you can be confident that your Ozempic remains effective after being stored at room temperature for one week, as this is well within the manufacturer's approved 56-day room temperature stability period.

References

Research

Stability of thermolabile drugs at room temperature. A review.

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2025

Research

Allowable room temperature excursions for refrigerated medications: A 20-year review.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2022

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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