From the Guidelines
Prochlorperazine is an over-the-counter (OTC) medication used for nausea.
OTC Medications for Nausea
- Prochlorperazine is a phenothiazine antipsychotic that reduces nausea and vomiting by inhibiting dopamine receptors in the brain 1.
Evidence for Prochlorperazine
- A study published in the Journal of the National Comprehensive Cancer Network found that prochlorperazine is effective in managing nausea and vomiting, with a recommended dosage of 25 mg suppository as needed every 12 h or 10 mg PO or IV every 4 or every 6 h 1.
- Another study published in the World Journal of Emergency Surgery recommends managing nausea and vomiting with medications that target dopaminergic pathways, such as prochlorperazine 1.
Other Options
- Ondansetron is a serotonin 5-HT3 antagonist that can be used to manage nausea and vomiting, but it is not always available OTC 1.
- Metoclopramide is a dopamine receptor antagonist that can be used to manage nausea and vomiting, but it is not always available OTC 1.
From the Research
Over-the-Counter (OTC) Medications for Nausea
- There are several antiemetic medications available, including serotonin antagonists, dopamine antagonists, antihistamines, and corticosteroids 2, 3.
- Some common OTC medications used for nausea include:
- Antihistamines, such as promethazine and prochlorperazine 4.
- Antacids and acid reducers, such as ranitidine and famotidine, which can help alleviate nausea caused by acid reflux or stomach upset.
- However, it's worth noting that the effectiveness of OTC antiemetics can vary depending on the individual and the cause of nausea 5.
- In some cases, prescription medications like ondansetron may be more effective for severe nausea and vomiting 4.
Mechanisms of Action
- Antiemetic medications can work through various mechanisms, including: