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Last updated: October 14, 2025View editorial policy

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Differential Diagnosis for Continuous Cough

Single Most Likely Diagnosis

  • Chronic Bronchitis: This is often the most common cause of a continuous cough, especially in smokers or those exposed to pollutants. The chronic inflammation of the bronchial tubes leads to a persistent cough.

Other Likely Diagnoses

  • Asthma: A condition characterized by episodic airway constriction, which can cause a chronic cough, especially at night or with exertion.
  • Gastroesophageal Reflux Disease (GERD): Stomach acid reflux can irritate the throat, leading to a persistent cough.
  • Allergic Rhinitis: Postnasal drip from allergies can cause a continuous cough.
  • Upper Respiratory Tract Infections: Viral or bacterial infections like the common cold or sinusitis can lead to a prolonged cough.

Do Not Miss Diagnoses

  • Lung Cancer: Although less common, lung cancer can present with a persistent cough, making it crucial not to miss this diagnosis, especially in smokers or those with a family history.
  • Tuberculosis (TB): A bacterial infection that can cause a chronic cough, often accompanied by other symptoms like weight loss and night sweats.
  • Pneumonia: Bacterial or viral pneumonia can cause a severe, persistent cough.
  • Pulmonary Embolism: A blood clot in the lungs can cause a sudden onset of cough, among other symptoms like chest pain and shortness of breath.

Rare Diagnoses

  • Cystic Fibrosis: A genetic disorder that leads to the production of thick mucus, causing chronic respiratory infections and cough.
  • Sarcoidosis: An inflammatory disease that can affect the lungs, leading to a persistent cough among other symptoms.
  • Bronchiectasis: A condition where the airways are permanently enlarged, leading to chronic infections and cough.
  • Interstitial Lung Disease: A group of disorders that cause scarring of the lung tissue, leading to symptoms including a persistent cough.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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