Renal Colic: This is often the first consideration for abdominal colic due to its prevalence and the severity of pain it causes. Renal colic is characterized by severe, episodic pain, typically starting in the flank and radiating to the groin, associated with kidney stones.

Biliary Colic: Caused by gallstones, this condition presents with intermittent, severe pain in the right upper quadrant of the abdomen, often triggered by fatty meals.
Intestinal Obstruction: This can cause colicky abdominal pain, especially if the obstruction is partial or intermittent. Vomiting, constipation, and abdominal distension may also be present.
Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease and ulcerative colitis can cause chronic or recurrent abdominal pain, which may have a colicky nature, along with diarrhea, weight loss, and other symptoms.
Diverticulitis: Inflammation of a diverticulum in the wall of the colon can cause severe, usually constant pain, but may have a colicky component, typically in the lower left abdomen.

Appendicitis: Although the pain of appendicitis is often described as constant and worsening over time, it can start as colicky. It's crucial to consider appendicitis due to the potential for severe complications if not promptly treated.
Ectopic Pregnancy: In women of childbearing age, ectopic pregnancy is a critical diagnosis to consider, as it can present with severe, colicky abdominal pain and is life-threatening if not promptly diagnosed and treated.
Aortic Dissection: This is a medical emergency that can cause severe, tearing chest pain that may radiate to the abdomen, presenting as colic. It requires immediate recognition and treatment.
Mesenteric Ischemia: This condition, involving insufficient blood flow to the intestines, can cause severe abdominal pain out of proportion to the physical examination findings, and it is critical to diagnose early to prevent intestinal infarction.

Lead Poisoning: Can cause abdominal colic, among other symptoms, due to its effect on the nervous system and smooth muscle.
Porphyrias: A group of rare genetic disorders that can cause acute intermittent porphyria, characterized by severe abdominal pain, among other symptoms.
Abdominal Migraine: A condition that can cause recurrent episodes of severe abdominal pain, often accompanied by other migraine symptoms like headache and nausea.