From the Guidelines
Taurine may play a beneficial role in chronic kidney disease (CKD) by potentially slowing disease progression and addressing complications, although the current evidence does not specifically support its use in CKD management, as noted in recent guidelines such as those from the Kidney Disease: Improving Global Outcomes (KDIGO) 1. Taurine is an amino acid with antioxidant and anti-inflammatory properties that can help protect kidney cells from oxidative damage. For CKD patients, supplementation typically ranges from 500-2000 mg daily, divided into two doses, though no official dosing guidelines exist specifically for kidney disease. Taurine appears to help regulate blood pressure, reduce inflammation, decrease proteinuria, and improve insulin sensitivity—all important factors in managing CKD. It may also help address anemia and mineral bone disorders associated with kidney dysfunction. Taurine works by stabilizing cell membranes, regulating calcium levels, neutralizing free radicals, and modulating inflammatory pathways. While generally considered safe, patients should consult their nephrologist before starting supplements, as taurine might interact with certain medications. Dietary sources include fish, meat, and dairy, though these must be balanced with protein restrictions often recommended in CKD. Patients with end-stage renal disease may have lower taurine levels due to dialysis losses, making supplementation potentially more relevant for this population, as suggested by studies on the management of patients with CKD and end-stage renal disease 1. However, the most recent and highest quality evidence should be consulted for the latest recommendations on CKD management, including the use of sodium-glucose cotransporter-2 (SGLT-2) inhibitors, which have shown promise in reducing the risk of kidney failure and cardiovascular events in patients with CKD, regardless of diabetes status 1.
From the Research
Role of Taurine in Chronic Kidney Disease (CKD)
- Taurine has been studied for its potential role in preventing the progression of CKD, with some studies suggesting that it may have a beneficial effect on kidney function 2.
- A study published in 2022 found that supplementation with taurine and N-acetylcysteine, in combination with a low-protein diet, may help to slow the progression of CKD in non-diabetic patients 2.
- Another study published in 2022 discussed the role of antioxidants, including taurine, in the prevention and treatment of CKD, highlighting their potential to control oxidative stress and slow disease progression 3.
- A review article published in 2012 examined the role of taurine in renal disorders, including CKD, and discussed its potential mechanisms of action and clinical significance 4.
- However, it is worth noting that the current evidence is not sufficient to draw definitive conclusions about the role of taurine in CKD, and further research is needed to fully understand its effects 5, 6.
Key Findings
- Taurine may have a beneficial effect on kidney function in CKD patients, particularly when combined with other antioxidants and a low-protein diet 2.
- Antioxidants, including taurine, may help to control oxidative stress and slow the progression of CKD 3.
- The potential mechanisms of taurine action in CKD include its antioxidant and anti-inflammatory effects, as well as its ability to regulate renal function and prevent proteinuria 4.