Differential Diagnosis for Daily Twitching of Eyelid

• Single most likely diagnosis
  • Essential Blepharospasm: This is a condition characterized by involuntary twitching or spasms of the eyelid muscles. It is the most common cause of eyelid twitching and can be triggered by fatigue, stress, or caffeine.
• Other Likely diagnoses
  • Hemifacial Spasm: A rare neurological disorder characterized by irregular, involuntary muscle contractions on one side of the face, including the eyelid.
  • Tic Disorder: Conditions like Tourette's syndrome can cause involuntary movements, including eyelid twitching.
  • Caffeine or Medication-induced Twitching: Excessive caffeine consumption or certain medications can lead to eyelid twitching.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Multiple Sclerosis: Although rare, multiple sclerosis can cause eyelid twitching as part of its broader neurological symptoms.
  • Thyroid Eye Disease: This condition can cause eyelid twitching among other symptoms like bulging eyes and double vision.
  • Botulism: A rare but serious illness that can cause muscle weakness, including eyelid twitching.
• Rare diagnoses
  • Dystonia: A neurological disorder that causes involuntary muscle contractions, which can include eyelid twitching.
  • Chorea: A neurological disorder characterized by involuntary, unpredictable body movements, which can include eyelid twitching.
  • Neurodegenerative Diseases (e.g., Parkinson's Disease): Certain neurodegenerative diseases can cause eyelid twitching as part of their symptomatology, although this is less common.