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Last updated: October 15, 2025View editorial policy

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Differential Diagnosis

The patient presents with symptoms of a chest infection, including chest burning, cough with green phlegm, fever, and shortness of breath. The following differential diagnoses are considered:

  • Single Most Likely Diagnosis
    • Acute bronchitis: The patient's symptoms of cough with green phlegm, fever, and chest burning are consistent with acute bronchitis, a common condition in adults, especially in those with a history of smoking.
  • Other Likely Diagnoses
    • Community-acquired pneumonia (CAP): Although the patient's oxygen saturation is normal and there are no crackles on lung exam, CAP is still a possibility, especially given the fever, cough, and green phlegm.
    • Acute exacerbation of asthma: The patient has a history of asthma, and although it is reported as inactive, the symptoms of cough, shortness of breath, and chest burning could be indicative of an exacerbation.
    • Influenza: The patient's symptoms of fever, cough, and sore throat, although mild, could be consistent with influenza, especially during the flu season.
  • Do Not Miss Diagnoses
    • Pulmonary embolism (PE): Although the patient's symptoms do not strongly suggest PE, it is a potentially life-threatening condition that must be considered, especially in patients with risk factors such as recent surgery or immobility.
    • Myocardial infarction (MI): The patient's chest pain described as a burning sensation could be atypical for MI, and although the patient's cardiovascular exam is normal, MI must be considered in any patient with chest pain.
    • Pneumonia due to a more unusual organism (e.g., Legionella, Mycoplasma): These organisms can cause atypical presentations of pneumonia, and a high index of suspicion is necessary to diagnose them.
  • Rare Diagnoses
    • Tuberculosis (TB): Although the patient's symptoms are not strongly suggestive of TB, it is a possibility, especially in patients with a history of smoking or other risk factors.
    • Lung cancer: The patient's history of smoking and recent onset of symptoms could raise the possibility of lung cancer, although it is less likely given the acute presentation.
    • Sarcoidosis: This condition can cause a variety of respiratory symptoms, including cough and shortness of breath, although it is less likely given the patient's acute presentation.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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