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Last updated: October 15, 2025View editorial policy

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Differential Diagnosis for Skin Lesion

Without seeing the picture, we can still provide a general differential diagnosis based on common skin lesions. Here's a categorized list:

  • Single Most Likely Diagnosis
    • Eczema/Dermatitis: This is a common condition that can cause a variety of skin lesions, including redness, itching, and small bumps. It's often seen in individuals with a history of allergies or asthma.
  • Other Likely Diagnoses
    • Acne: A common skin condition that causes pimples, especially on the face, but can appear on other parts of the body as well.
    • Psoriasis: An autoimmune condition that speeds up the life cycle of skin cells, causing cells to build up rapidly on the surface of the skin. The extra skin cells form scales and red patches that are itchy and sometimes painful.
    • Keratosis Pilaris: A harmless condition that causes small, rough patches on the skin, often on the arms, thighs, cheeks, and buttocks.
  • Do Not Miss Diagnoses
    • Skin Cancer (Melanoma, Basal Cell Carcinoma, Squamous Cell Carcinoma): Although less common, skin cancers can present as unusual skin lesions. Early detection is crucial for effective treatment.
    • Infectious Lesions (Cellulitis, Abscess): Bacterial infections of the skin can cause a range of symptoms from mild to severe, including redness, swelling, warmth, and pus.
    • Lyme Disease: Caused by a tick bite, it can lead to a distinctive "bull's-eye" rash, among other symptoms.
  • Rare Diagnoses
    • Mycosis Fungoides: A rare type of cutaneous T-cell lymphoma that can cause skin lesions, including patches, plaques, and tumors.
    • Sarcoidosis: A condition that can cause small, grain-of-rice-sized bumps under the skin, often on the face, arms, or legs, due to the growth of tiny collections of inflammatory cells.
    • Vasculitis: Inflammation of the blood vessels, which can cause a variety of skin lesions, including purpura (bleeding under the skin), ulcers, and nodules.

Each of these conditions has distinct characteristics, and a proper diagnosis would require a detailed examination of the lesion, medical history, and possibly additional tests.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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