Can hydrazine be taken with Isordil (Isosorbide dinitrate)?

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From the Guidelines

I strongly advise against taking hydrazine with Isordil (isosorbide dinitrate) due to the potential for severe adverse effects and the lack of medical approval for hydrazine consumption. Hydrazine is a highly toxic industrial chemical that can cause severe liver damage, nervous system effects, and is potentially carcinogenic 1. In contrast, Isordil is a medication used to treat angina and heart failure, and its efficacy and safety have been established in clinical trials 1.

Key Considerations

  • The combination of hydralazine and isosorbide dinitrate has been studied in the context of heart failure treatment, and the fixed-dose combination is recommended for certain patients 1.
  • However, hydrazine is not a medication and has no established medical use, making it unsafe for human consumption.
  • The potential risks of taking hydrazine with Isordil include interference with the medication's efficacy, increased risk of adverse effects, and potential long-term health consequences.

Recommendations

  • If you are considering taking any substance with Isordil, consult your healthcare provider to discuss the potential risks and benefits.
  • If you are experiencing issues with your current medication regimen, seek proper medical advice rather than experimenting with industrial chemicals.
  • The fixed-dose combination of isosorbide dinitrate and hydralazine is a recommended treatment option for certain patients with heart failure, but this should only be used under the guidance of a healthcare provider 1.

Important Distinctions

  • Hydrazine is not a medication and should not be confused with hydralazine, which is a medication used in combination with isosorbide dinitrate for heart failure treatment 1.
  • The safety and efficacy of Isordil have been established in clinical trials, and it should only be used as directed by a healthcare provider 1.

From the Research

Interaction between Hydrazine and Isordil (Isosorbide Dinitrate)

  • There are no research papers to assist in answering this question, as none of the provided studies 2, 3, 4, 5, 6 investigate the interaction between hydrazine and Isordil (Isosorbide Dinitrate).

Available Information on Isordil (Isosorbide Dinitrate)

  • The studies provided focus on the efficacy and safety of Isordil (Isosorbide Dinitrate) in treating angina pectoris, either alone or in combination with other medications 2, 3, 4, 5, 6.
  • They discuss the effects of Isordil on coronary artery blood supply, cardiac preload, and afterload, as well as its potential interactions with other medications, such as calcium antagonists 2 and diltiazem 6.
  • However, none of these studies mention hydrazine or its potential interaction with Isordil.

References

1
Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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