From the Guidelines

Ocular pain associated with a viral upper respiratory infection (URI) is typically treated with a multidisciplinary approach.

Topical nerve regenerative therapies, such as autologous serum tears, can be used for peripheral neuropathic ocular pain (NOP) 1.
Oral neuromodulators, like pregabalin, gabapentin, duloxetine, amitriptyline, nortriptyline, and low-dose naltrexone, can be used alone or in combination for individuals with a central component to pain or systemic comorbidities 1.
Adjuvant strategies, such as using a transcutaneous electrical nerve stimulation device and periorbital botulinum toxin A injections, can be considered for individuals with light sensitivity and headache 1.
Complimentary therapies, like acupuncture, cognitive behavioral therapy, or hypnosis, should be considered to address the emotional component of pain 1.

Early detection and treatment of the underlying cause of conjunctivitis is crucial to reduce the public health and economic impact of community spread 1.
Indiscriminate use of topical antibiotics or corticosteroids should be avoided, as they can induce toxicity or worsen certain infections 1.
A thorough review of systems may help identify nonocular symptoms and underlying systemic disorders 1.

From the Research

The treatment for ocular pain associated with a viral upper respiratory infection (URI) is primarily focused on relieving symptoms, as there is no specific cure for viral infections 2.
Pain relief may be achieved with oral analgesics and cycloplegics, which can help reduce discomfort and inflammation in the eye 2.
Supportive care options, such as artificial tears and cold compresses, can also be used to alleviate symptoms of viral conjunctivitis, which may be associated with a viral URI 3.
In some cases, antihistamine eye drops may be used to relieve itching and redness associated with allergic conjunctivitis, which can be triggered by a viral URI 3.
It is essential to practice strict personal hygiene, including frequent handwashing, to decrease the risk of transmission of viral conjunctivitis 3.

If the ocular pain is severe or accompanied by other symptoms such as decreased vision, recent ocular surgery, or a vesicular rash on the eyelids or nose, referral to an ophthalmologist is indicated 4, 3.
In cases where the diagnosis is unclear or the patient has a history of rheumatologic disease or immunocompromised state, further evaluation and treatment by an ophthalmologist may be necessary 3.
The treatment approach should be governed by the severity of symptoms and the magnitude of possible consequences, and aggressive management may be required in severe cases 4.