Is low-level laser therapy (LLLT) or photobiomodulation (PBM) effective?

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Last updated: March 24, 2025View editorial policy

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From the Guidelines

Low-level laser therapy (LLLT) or photobiomodulation (PBM) is effective for improving pain and function in certain conditions, such as low back pain, according to the most recent and highest quality study 1. The effectiveness of LLLT or PBM has been evaluated in various studies, with some showing positive results for pain relief and functional improvement. For example, a study found that LLLT combined with NSAIDs decreased pain intensity and improved function in patients with acute or subacute low back pain 1. Key points to consider when using LLLT or PBM include:

  • The therapy can be used in conjunction with other noninvasive nonpharmacologic approaches, such as exercise, physical therapy, and behavioral therapies, to improve pain and function.
  • The evidence for LLLT or PBM is generally low-quality, but it may be considered as a supplementary treatment for patients who have not responded to other therapies.
  • Patients should maintain realistic expectations and follow device instructions carefully when using LLLT or PBM, and consult healthcare providers, especially for serious medical conditions where it should not replace conventional treatments. Some of the benefits of LLLT or PBM include:
  • Improved pain relief and functional improvement in certain conditions, such as low back pain.
  • Potential for reduced inflammation and aid in healing.
  • Noninvasive and relatively low-risk treatment option. However, it is essential to note that:
  • The evidence for LLLT or PBM is not strong, and more research is needed to fully understand its effects.
  • Results may vary significantly between individuals, and many claims lack robust scientific support.
  • LLLT or PBM should not be used as a replacement for conventional treatments, especially for serious medical conditions.

From the Research

Effectiveness of Low-Level Laser Therapy (LLLT) or Photobiomodulation (PBM)

  • LLLT or PBM has been shown to be effective in promoting wound healing, reducing inflammation, and improving tissue repair 2, 3, 4, 5.
  • Studies have demonstrated that different wavelengths of light, including red, near-infrared, and blue, can have beneficial effects on wound healing 2, 3, 4, 5.
  • The use of light-emitting diodes (LEDs) has been found to be a effective and non-invasive means of delivering LLLT or PBM, with similar biological effects to laser therapy 6.
  • The effectiveness of LLLT or PBM is dependent on various parameters, including wavelength, dose, and treatment duration 3, 6.

Wound Healing Outcomes

  • LLLT or PBM has been shown to enhance wound healing by increasing angiogenesis, improving tissue perfusion, and reducing tissue necrosis 2, 4, 5.
  • Studies have demonstrated that LLLT or PBM can improve wound healing outcomes in various types of wounds, including acute and chronic wounds, and wounds with compromised blood flow 2, 3, 4, 5.
  • The use of LLLT or PBM has also been found to reduce pain and discomfort associated with wound healing 2.

Comparison of LED and Laser Therapy

  • Studies have compared the effectiveness of LED and laser therapy in promoting wound healing, with similar biological effects observed for both modalities 6.
  • The use of LED therapy has been found to be a cost-effective and non-invasive means of delivering LLLT or PBM, with similar outcomes to laser therapy 6.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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